Results 101 to 110 of about 7,802 (179)

Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin

Frontiers in Genetics
Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate incorporation of amino acids at the stop codon and production of full-length, often ...
Kamila Pawlicka, Tomas Henek, Lukas Uhrik, Lenka Hernychova, Monikaben Padariya, Jakub Faktor, Sławomir Makowiec, Borivoj Vojtesek, Borivoj Vojtesek, David Goodlett, Ted Hupp, Ted Hupp, Umesh Kalathiya   +12 more
doaj   +1 more source

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization [PDF]

, 2016
Selenoproteins are proteins that incorporate selenocysteine (Sec), a nonstandard amino acid encoded by UGA, normally a stop codon. Sec synthesis requires the enzyme Selenophosphate synthetase (SPS or SelD), conserved in all prokaryotic and eukaryotic ...
Arnan, Carme, Capella Gutiérrez, Salvador Jesús, 1985-, Corominas, Montserrat (Corominas Guiu), D'Aniello, Salvatore, Gabaldón, Toni, Gladyshev, Vadim N., Guigó Serra, Roderic, Hee-Yim, Sun, Johnson, Rary, Mariotti, Marco, 1984-, Mateo, Andrea, Santesmasses, Didac, Serras Rigalt, Florenci   +12 more
core   +1 more source

Cross‐Species Insights Into Gamma Herpesvirus Transcriptomes: Long‐Read and Multi‐Omics Perspectives

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Ritu Shekhar, Sarah McMahon, Scott A. Tibbetts, Erik K. Flemington, Rolf Renne   +4 more
wiley   +1 more source

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Cells, 2019
In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as ...
Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield   +3 more
doaj   +1 more source

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. [PDF]

, 2017
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis ...
Atanasova, Velina S., Bruckner-Tuderman, Leena, Chen, Mei, Gruber, Christina, Has, Cristina, Hofbauer, Josefina Piñón, Jiang, Qiujie, McGrath, John A., Prisco, Marco, South, Andrew P., Uitto, Jouni   +10 more
core   +1 more source

Quantitative nucleotide level analysis of regulation of translation in response to depolarization of cultured neural cells [PDF]

, 2017
Studies on regulation of gene expression have contributed substantially to understanding mechanisms for the long-term activity-dependent alterations in neural connectivity that are thought to mediate learning and memory.
Dalal, Jasbir S, Dougherty, Joseph D, Lake, Allison M, O\u27Brien, David R, Sapkota, Darshan, Yang, Chengran   +5 more
core   +2 more sources

Delayed‐onset cord1 progressive retinal atrophy in English Springer Spaniels genetically affected with the RPGRIP1 variant

Veterinary Ophthalmology, Volume 29, Issue 1, January 2026.
Abstract Objective Cone‐rod dystrophy (cord1) is a form of progressive retinal atrophy. It is linked to an RPGRIP1 genetic variant which is the third most common canine disease variant thus far. While the variant affects various breeds, it is highly prevalent in English Springer Spaniels (ESSs).
Jennifer C. Kwok, Yu Sato, Jessica K. Niggel, Emma Ozdogan, Leonardo Murgiano, Keiko Miyadera   +5 more
wiley   +1 more source

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P [PDF]

, 2017
Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading.
Everley, Robert A., Gladyshev, Vadim N., Gygi, Steven P., Heynisch, Bjoern, Hybsier, Sandra, Köhrle, Josef, Martitz, Janine, Renko, Kostja, Schomburg, Lutz, Stoedter, Mette, Voss, Linn, Wisniewska, Monika   +11 more
core   +1 more source

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, Volume 604, Issue 2, Page 849-867, 15 January 2026.
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina, Sean Y. Ng, Andrew I. Mikhail, Derek W. Stouth, Cora E. Jornacion, Irena A. Rebalka, Thomas J. Hawke, Vladimir Ljubicic   +7 more
wiley   +1 more source

Phycobilisome rod mutants in Synechocystis sp. strain PCC6803 [PDF]

, 2004
The phycobilisome is a large pigment-protein assembly that harvests light energy for photosynthesis. This supramolecular complex is composed of two main structures: a core substructure and peripheral rods.
Ajlani, Ghada, Ughy, Bettina
core   +4 more sources