Results 51 to 60 of about 7,802 (179)

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials [PDF]

, 2017
To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates.
Ahyong, Alhebshi, Alonso, Ausubel, Avery, Baragana, Barthelme, Becker, Becker, Beznoskova, Bilsland, Carter, Cervantes, Choi, Cindy Vallières, Cokol, Dever, Duina, Eurwilaichitr, Fan-Minogue, Farabaugh, Flannery, Foucquier, Ghorbal, Gietz, Goodman, Hain, Holland, Holland, Hsieh, Imlay, Islahudin, Islahudin, Jackson, Jenkins, Keeling, Kessl, Kessl, Khoshnevis, Khozoie, Kraft, Laleve, Lehane, Li, Loenarz, Moore, Moreno-Martinez, Nurenberg, Petersen, Pulcini, Py, Radfar, Salas-Marco, Simon V. Avery, Slavic, Song, Sorensen, Spangenberg, Tafazoli, Tarlov, Vaidya, Vallieres, Van Voorhis, WHO, Wu, Zhang   +65 more
core   +3 more sources

Hominini-specific regulation of the cell cycle by stop codon readthrough of FEM1B.

J Cell Sci
ABSTRACT FEM1B is a substrate-recognition component of the CRL2 E3 ubiquitin-protein ligase. This multi-protein complex targets specific proteins for ubiquitylation, which leads to their degradation. Here, we demonstrate the regulation of FEM1B expression by stop codon readthrough (SCR). In this process, translating ribosomes readthrough
Akhtar MN, Singh A, Manjunath LE, Dey D, Kumar SD, Vasu K, Das A, Eswarappa SM.   +7 more
europepmc   +4 more sources

Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model [PDF]

, 2016
Choroideremia (CHM) is an X-linked chorioretinal dystrophy that is caused by mutations within a single gene, CHM Currently no effective treatment exists for these patients.
Coffey, P, da Cruz, L, Kalatzis, V, Moosajee, M, Smart, M, Torriano, S, Tracey-White, D, Webster, AR, Weetall, M, Welch, E   +9 more
core   +1 more source

Ribosome profiling of the retrovirus murine leukemia virus

Retrovirology, 2018
Background The retrovirus murine leukemia virus (MuLV) has an 8.3 kb RNA genome with a simple 5′-gag-pol-env-3′ architecture. Translation of the pol gene is dependent upon readthrough of the gag UAG stop codon; whereas the env gene is translated from ...
Nerea Irigoyen, Adam M. Dinan, Ian Brierley, Andrew E. Firth   +3 more
doaj   +1 more source

From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion

Viruses, 2021
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins, Kate M. O’Connor, Pramod R. Bhatt, Gary Loughran   +3 more
doaj   +1 more source

Maize chlorotic mottle virus exhibits low divergence between differentiated regional sub-populations. [PDF]

, 2018
Maize chlorotic mottle virus has been rapidly spreading around the globe over the past decade. The interactions of maize chlorotic mottle virus with Potyviridae viruses causes an aggressive synergistic viral condition - maize lethal necrosis, which can ...
Baulcombe, David C, Braidwood, Luke, Bressan, Alberto, Cabanas, Darlene, Quito-Avila, Diego F, Wangai, Anne   +5 more
core   +2 more sources

Multifaceted regulation of translational readthrough by RNA replication elements in a tombusvirus. [PDF]

PLoS Pathogens, 2011
Translational readthrough of stop codons by ribosomes is a recoding event used by a variety of viruses, including plus-strand RNA tombusviruses. Translation of the viral RNA-dependent RNA polymerase (RdRp) in tombusviruses is mediated using this strategy
Peter A Cimino, Beth L Nicholson, Baodong Wu, Wei Xu, K Andrew White   +4 more
doaj   +1 more source

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement. [PDF]

, 2015
Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae.
Brault, Véronique, Chung, Betty, Firth, Andrew, Miller, W. Allen, Miller, W. Allen, Rakotondrafara, Aurélie, Reinbold, Catherine, Scheidecker, Danièle, Smirnova, Ekaterina, Ziegler-Graff, Véronique   +9 more
core   +9 more sources

Identification of compounds enhancingAqp4stop codon readthrough [PDF]

, 2020
AbstractAn unusual stop codon readthrough event generates a conserved C-terminally elongated variant of the water channel protein Aquaporin 4 (AQP4). In the brain, AQP4 is astrocyte-specific, required for normal functioning of the glymphatic system, and involved in the clearance of the Alzheimer’s associated protein Amyloid beta.
D. Sapkota, J.D. Dougherty
openaire   +1 more source

Running the Stop Sign: Readthrough of a Premature UAG Termination Signal in the Translation of a Zebrafish (Danio rerio) Taurine Biosynthetic Enzyme

Marine Drugs, 2017
The UAG termination codon is generally recognized as the least efficient and least frequently used of the three universal stop codons. This is substantiated by numerous studies in an array of organisms.
Mary E.M. Larkin, Allen R. Place
doaj   +1 more source