Computational analysis of stop codon readthrough in D.melanogaster [PDF]
Bioinformatics, 2003 Abstract Motivation: Readthrough is an unusual process in which a stop codon is misread or skipped. Recently it has been shown that some translation is regulated by the readthrough reactions although the complete mechanism is not clear.
Misaki, Sato +4 more
openaire +2 more sources
Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness. [PDF]
Mol Cell, 2017 Fan Y +8 more
europepmc +2 more sources
Identification of stop codon readthrough genes in Saccharomyces cerevisiae [PDF]
Nucleic Acids Research, 2003 We specifically sought genes within the yeast genome controlled by a non-conventional translation mechanism involving the stop codon. For this reason, we designed a computer program using the yeast database genomic regions, and seeking two adjacent open reading frames separated only by a unique stop codon (called SORFs).
Olivier, Namy +5 more
openaire +2 more sources
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
Cell Death and Disease, 2022 TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53.
Mireia Palomar-Siles +12 more
doaj +1 more source
Pseudouridine-mediated stop codon readthrough in S. cerevisiae is sequence context-independent. [PDF]
RNA, 2020 We have previously shown that when the uridine of a stop codon (UAA, UAG, or UGA) is pseudouridylated, the ribosome reads through the modified stop codon. However, it is not clear as to whether or not the pseudouridine (Ψ)-mediated readthrough is dependent on the sequence context of mRNA.
Adachi H, Yu YT.
europepmc +4 more sources
Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response. [PDF]
J Biol Chem, 2018 Loughran G +7 more
europepmc +2 more sources
Control of gene expression in the retrotransposon Tca2 [PDF]
, 2007 BACKGROUND:In the C. albicans retrotransposon Tca2, the gag and pol ORFs are separated by a UGA stop codon, 3' of which is a potential RNA pseudoknot. It is unclear how the Tca2 gag UGA codon is bypassed to allow pol expression.
Brunton, Fiona +5 more
core +3 more sources
Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
Frontiers in Pharmacology, 2022 BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu +10 more
doaj +1 more source
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]
, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A. +6 more
core +1 more source
RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming
Angewandte Chemie, EarlyView.RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh +3 more
wiley +2 more sources