Results 101 to 110 of about 815,824 (234)

The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection

Viruses
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles.
Niklas Jäger, Shreya Ahana Ayyub, Frank Peske, David Liedtke, Jens Bohne, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +7 more
doaj   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids

Nature Communications
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, the yields of most ncAA-containing protein  remain low due to the limited activity of PylRS variants.
Qunfeng Zhang, Ling Jiang, Yadan Niu, Yujie Li, Wanyi Chen, Jingxi Cheng, Haote Ding, Binbin Chen, Ke Liu, Jiawen Cao, Junli Wang, Shilin Ye, Lirong Yang, Jianping Wu, Gang Xu, Jianping Lin, Haoran Yu   +16 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis

Nature Communications
N 6-methyladenosine (m6A) plays critical roles in regulating mRNA metabolism. However, comprehensive m6A methylomes in different plant tissues with single-base precision have yet to be reported. Here, we present transcriptome-wide m6A maps at single-base
Guanqun Wang, Haoxuan Li, Chang Ye, Kayla He, Shun Liu, Bochen Jiang, Ruiqi Ge, Boyang Gao, Jiangbo Wei, Yutao Zhao, Aixuan Li, Di Zhang, Jianhua Zhang, Chuan He   +13 more
doaj   +1 more source

A population-specific HTR2B stop codon predisposes to severe impulsivity

, 2010
Impulsivity, describing action without foresight, is an important feature of several psychiatric diseases, suicidality and violent behaviour. The complex origins of impulsivity hinder identification of the genes influencing it and the diseases with which
Luc Maroteaux, Matti Virkkunen, Qiaoping Yuan, Rose, Richard J., DOLY S, Emil Coccaro, Dell’Osso, Liliana, YUAN Q, Zhifeng Zhou, ROSE RJ, SUVISAARI J, Belmer, Arnaud, DIAZ S, VIRKKUNEN M, Diaz, Silvina, L., COCCARO E, HODGKINSON CA, WEDENOJA J, Paunio, Tiina, Hodgkinson, Colin, A., Jaakko Kaprio, Doly, Stephane, Virkkunen, Matti, Kaprio, Jaakko, Yuan, Qiaoping, Peltonen, Leena, BELMER A, Diaz, Silvina, KAPRIO J, Suvisaari, Jaana, TIKKANEN R, Belmer, Arnauld, Dell'Osso, Liliana, Stéphane Doly, Roope Tikkanen, Laura Bevilacqua, Bevilacqua, Laura, Wedenoja, Juho, MAROTEAUX L, Liliana Dell’Osso, Zhou, Zhifeng, Jaana Suvisaari, Leena Peltonen, Tikkanen, Roope, Colin A. Hodgkinson, Tiina Paunio, Arnaud Belmer, ZHOU Z, David Goldman, PAUNIO T, GOLDMAN D., Richard J. Rose, Goldman, David, Hodgkinson, Colin A., BEVILACQUA L, Rose, Richard, J., PELTONEN L, Maroteaux, Luc, Juho Wedenoja, Coccaro, Emil, Silvina Diaz   +60 more
core   +1 more source