Results 121 to 130 of about 17,020 (309)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

THE SUM OF ACTIVE TEMPERATURES AS A METHOD OF DETERMINING THE OPTIMUM HARVEST DATE OF ’ŠAMPION’ AND ‘LIGOL’ APPLE CULTIVARS

Acta Scientiarum Polonorum: Hortorum Cultus, 2012
The harvest date is crucial for the storability of autumn apple cultivars like ’Šampion’ and winter apples cultivars like ‘Ligol’ intended for long storage.
Grzegorz Łysiak
doaj  

Analysis of difference in storability and flavor of yellow peaches with different maturities at non-chilling injury temperatures

Shipin yu jixie
ObjectiveTo study the flavor changes of yellow peaches with different maturities at non-chilling injury temperatures (12~15 ℃), as well as to determine the quality deterioration point and safe storage period.MethodsUsing 70%-, 80%- and 90%-ripened ...
ZHOU Xun, ZHOU Huijuan, HUANG Lingxiang, YE Zhengwen, SU Mingshen, DU Jihong, ZHANG Xianan, LI Xiongwei, ZHANG Minghao   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Physiological and isozyme alterations in lettuce seeds under different conditions and storage periods

Journal of Seed Science
: The objective of the study was to determine the physiological and isozyme alterations in lettuce seeds submitted to different conditions and storage periods.
Hugo César Rodrigues Moreira Catão, Luiz Antonio Augusto Gomes, Renato Mendes Guimarães, Pedro Henrique Faria Fonseca, Franciele Caixeta, Josué Clock Marodin   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimisation of polyphenol extraction from Chinese Baijiu distillers' spent grains: Stability and antioxidant capacity

Czech Journal of Food Sciences
Chinese Baijiu distillers' spent grains (DSGs), a major byproduct of liquor production containing valuable polyphenols, face disposal challenges because of their high moisture content and rapid spoilage.
Caihong Xu, Xi Chen, Ping Yang, Shengzhong Dong, Qingyu Yang   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

'Honeycrisp': the challenge of the apple crisp revolution

Fruit Research
'Honeycrisp' apples are a crisp cultivar known for their unique texture and flavor. This cultivar is considered revolutionary in the world of crispy apples due to its high value and strong consumer preference.
Yosef Al Shoffe, Terence Robinson, Gennaro Fazio, Emily Follett, Matthew Clark, James Luby, David Bedford, Lee Kalcsits, Gregory Peck   +8 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source