Results 181 to 190 of about 24,940 (314)

Benchmarking the nutrition-related commitments and practices of major Belgian food companies by industry sector and over time (2019-2023/2024). [PDF]

BMC Nutr
Dastoum S, Vandevijvere S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Association Between Product Attributes and Oral Nicotine Pouch Preference-Evidence From Online Stores. [PDF]

Nicotine Tob Res
Hardin A, Ahn S, Ma S, Thai V, Berman M, Mays D, Chen J, Paskett ED, Wagener TL, Shang C.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Uptake Assay of Ram Seminal Plasma Extracellular Vesicles to Sperm. [PDF]

Bio Protoc
Armani T, Nicolli AR, Zalazar L, Lobo JI, Arellano MB, Hozbor FA, Rio S, Martinez SP, Cesari A.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

DETERMINANTS OF PRICE ELASTICITIES FOR STORE BRANDS AND NATIONAL BRANDS OF CHEESE

A two-stage modeling process is developed to estimate factors that determine price sensitivities for store and national brands of cheese. Results show that several factors affect price sensitivities.
Huang, Min-Hsin, Hahn, David E., Jones, Eugene   +2 more
core  

Pushing the US nicotine pouch market: insights from Zyn's free can campaign in September 2025. [PDF]

Tob Control
Talbot EM, Ganz O, Jensen JK, Mays D, Rose SW, Ackerman C, Hrywna M, Lee JGL, Bover Manderski MT, Barnwell PV, Mercincavage M, Henriksen L, Delnevo CD.   +12 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

How does in-store and online shopping experiences influence repurchase intentions in Shandong, China? Roles of perceived value, brand trust, and customer satisfaction. [PDF]

PLoS One
Zhou S, Salleh Hudin N.
europepmc   +1 more source