Results 91 to 100 of about 2,199 (176)

Fusion protein of retinol‐binding protein and albumin domain III reduces liver fibrosis

EMBO Molecular Medicine, 2015
Activated hepatic stellate cells (HSCs) play a key role in liver fibrosis, and inactivating HSCs has been considered a promising therapeutic approach.
Hongsik Lee, Hyeyeun Jeong, Sangeun Park, Wonbaek Yoo, Soyoung Choi, Kyungmin Choi, Min‐Goo Lee, Mihwa Lee, DaeRyong Cha, Young‐Sik Kim, Jeeyoung Han, Wonkon Kim, Sun‐Hwa Park, Junseo Oh   +13 more
doaj   +1 more source

Scanning the sixth transmembrane helix of STRA6 for positions that enhance the sensitivity of STRA6 to MTSEA-biotin modification.

, 2013
Thirty two residues in or near the sixth transmembrane domain of STRA6 were each changed to cysteine. Each mutant was tested for STRA6-catalyzed retinol release from holo-RBP. Grey traces, no modification. Red traces, MTSEA-biotin modification.
Mariam Ter-Stepanian (478956), Ming Zhong (151097), Hui Sun (107933), Miki Kassai (478957), Riki Kawaguchi (58003)   +4 more
core   +1 more source

Real-time analysis of STRA6-catalyzed transport of retinol from holo-RBP to EGFP-CRBP-I.

, 2013
A. Schematic diagram of the use of retinol-EGFP FRET to monitor the transport of retinol from holo-RBP to EGFP-CRBP-I. FRET is indicated by an orange arrow. B and C.
Mariam Ter-Stepanian (478956), Ming Zhong (151097), Hui Sun (107933), Miki Kassai (478957), Riki Kawaguchi (58003)   +4 more
core   +1 more source

Comparative efficacy of pranoprofen with sodium hyaluronate or polyvinyl alcohol in postoperative dry eye and corneal endothelial function

Pakistan Journal of Pharmaceutical Sciences
Background: Dry eye following eye surgery represents a common obstacle to recovery and general life satisfaction. Pranoprofen, an anti-inflammatory drug, frequently co-administered with adjuvants such as sodium hyaluronate and polyvinyl alcohol ...
Huating Bi, Fang Xu
doaj   +1 more source

Scanning the seventh transmembrane helix of STRA6 for positions that enhance the sensitivity of STRA6 to MTSEA-biotin modification.

, 2013
Twenty eight residues in or near the seventh transmembrane domain of STRA6 were each changed to cysteine. Each mutant was tested for STRA6-catalyzed retinol release from holo-RBP. Grey traces, no modification. Red traces, MTSEA-biotin modification.
Mariam Ter-Stepanian (478956), Ming Zhong (151097), Hui Sun (107933), Miki Kassai (478957), Riki Kawaguchi (58003)   +4 more
core   +1 more source

Purification of STRA6 from Pichia pastoris.

, 2015
(A) Fed-batch fermentation of recombinant Pichia pastoris expressing STRA6-GFP. Changes in the wet cell weight of yeast (red line) and dissolved oxygen (blue line) are shown over time.
Conor J. Breen (713888), Kate McQuaid (713890), Richard O’Kennedy (713891), Hui Ma (290168), Darren S. Martin (713889), John B. C. Findlay (713892)   +5 more
core   +1 more source

Hexafluoropropylene oxide dimer acid exposure disrupts hepatic lipid metabolism by modulating the RBP4-STRA6 axis

Ecotoxicology and Environmental Safety
Hexafluoropropylene oxide dimer acid (GenX), an emerging per- and polyfluoroalkyl substance (PFAS) detected in environmental matrices and drinking water sources, raises significant environmental health concerns due to its persistence and potential ...
Xinyu Li, Qiaoli Zhou, Wenhua Wang, Wei Gu, Yufeng Qin, Guizhen Du   +5 more
doaj   +1 more source

STRA6: role in cellular retinol uptake and efflux.

Hepatobiliary surgery and nutrition, 2015
Distribution of vitamin A throughout the body is important to maintain retinoid function in peripheral tissues and to ensure optimal vision. A critical step of this process is the transport of vitamin A across cell membranes. Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated ...
Mary, Kelly, Johannes, von Lintig
openaire   +1 more source

The DNA methylation status of the vitamin A signaling associated with testicular degeneration induced by long-day photoperiods in Magang geese

Poultry Science
: Magang geese are typical short-day breeders whose reproductive behaviors are significantly influenced by photoperiod. Exposure to a long-day photoperiod results in testicular regression and spermatogenesis arrest in Magang geese.
Yuting Fu, Diyu Lai, Yanglong Xu, Jiaxin Liu, Yushuai Wang, Danli Jiang, Jianqiu Pan, Hongjia Ouyang, Yunbo Tian, Yunmao Huang, Xu Shen   +10 more
doaj   +1 more source

Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes

Biomolecules
Fetal Alcohol Spectrum Disorder (FASD) is a common neurodevelopmental disorder that affects an estimated 2–5% of North Americans. FASD is induced by prenatal alcohol exposure (PAE) during pregnancy and while there is a clear genetic contribution, few ...
Leo McKay, Berardino Petrelli, Molly Pind, James N. Reynolds, Richard F. Wintle, Albert E. Chudley, Britt Drögemöller, Abraham Fainsod, Stephen W. Scherer, Ana Hanlon-Dearman, Geoffrey G. Hicks   +10 more
doaj   +1 more source