Results 81 to 90 of about 2,199 (176)

Transport of vitamin A across blood‐tissue barriers is facilitated by STRA6

The FASEB Journal, 2016
ABSTRACT Vitamin A bound to retinol binding protein 4 (RBP4) constitutes the major transport mode for retinoids in fasting circulation. Emerging evidence suggests that membrane protein, STRA6 (stimulated by retinoic acid 6), is the RBP4 receptor and vitamin A channel; however, the role of STRA6 in vitamin A ...
Mary, Kelly, M Airanthi K, Widjaja-Adhi, Grzegorz, Palczewski, Johannes, von Lintig   +3 more
openaire   +3 more sources

Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children

Diabetes, Metabolic Syndrome and Obesity, 2020
Anastasia Boaghi,1 Raluca-Monica Pop,1,2 Simona Loredana Vasilache,3 Claudia Banescu,4 Adina Hutanu,5 Oana Cristina Marginean,6 Ionela Maria Pascanu1,7 1Department of Endocrinology, Mures County Hospital, Tȃrgu Mureș 540139, Romȃnia; 2Research ...
Boaghi A, Pop RM, Vasilache SL, Banescu C, Hutanu A, Marginean OC, Pascanu IM   +6 more
doaj  

Conventional and Shared Genetic Association Analysis Between Diabetes Mellitus and Sensorineural Hearing Loss

Human Mutation, Volume 2026, Issue 1, 2026.
Purpose This study aims to investigate the epidemiological and genetic associations between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) across different subtypes. Methods We analyzed 502,490 participants from the UK Biobank using multivariate logistic regression to examine the association between DM and SNHL, considering gender, age ...
Xiaoyu Wang, Ziyan Zhang, Ke Qiu, Yaxin Luo, Xiaowei Yi, Wendu Pang, Dan Jiang, Jianjun Ren, Yu Zhao, Neetu Rawal   +9 more
wiley   +1 more source

To see, or not to see: In the eye of Retinol and STRA6 signaling

Developmental Biology, 2011
Eye morphogenesis proceeds very early during embryogenesis and complete anophthalmia is often associated with major brain anomalies. Here we report a striking pair of human siblings with no eyes and no other clinical manifestations. Genetic mapping revealed a single amino-acid in frame deletion in the STRA6 gene which encodes the Retinol/Vitamin A ...
Ho, Lena, Shboul, Mohammad, Reversade, Bruno, Shen, Kimberle, Masri, Amira, Merriman, Barry   +5 more
openaire   +1 more source

Relationship Between Serum Metabolites of Carotenoids, Vitamin A, Vitamin E, and Clinical Parameters in COVID‐19 Patients

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Oxidative stress and inflammation play central roles in the immunopathogenesis of COVID‐19. In this study, we investigated whether circulating carotenoids, retinol, and vitamin E metabolites can distinguish COVID‐19 patients from healthy controls and discriminate disease severity.
Aysel Ozpinar, Ceyda Sonmez, Aleyna Baltacioglu, Osman Acar, Meltem Kilercik, Mustafa Cetiner, Mustafa Serteser, Jens Raila, Muhittin A. Serdar, Florian J. Schweigert, Sancha Vale   +10 more
wiley   +1 more source

Identification of Potential Common Pathogenic Mechanisms Underlying Osteoarthritis and Major Depressive Disorder Using Bioinformatics Analysis

Immunity, Inflammation and Disease, Volume 13, Issue 11, November 2025.
ABSTRACT Background Patients with osteoarthritis (OA) exhibit an elevated risk for major depressive disorder (MDD), primarily due to chronic pain and associated disability. However, the shared molecular mechanisms underlying these conditions remain poorly understood.
Taiyuan Guan, Peixin Li, Sijian Su, Liang Ao, Xin Zhou   +4 more
wiley   +1 more source

RBP4 promotes denervation‐induced muscle atrophy through STRA6‐dependent pathway

Journal of Cachexia, Sarcopenia and Muscle
Backgrounds Fat infiltration of skeletal muscle has been recognized as a common feature of many degenerative muscle disorders. Retinol binding protein 4 (RBP4) is an adipokine that has been demonstrated to be correlated with the presence and severity of ...
Kang‐Zhen Zhang, Jia‐Wen Li, Jin‐Shui Xu, Zheng‐Kai Shen, Yu‐Shuang Lin, Can Zhao, Xiang Lu, Yun‐Feng Rui, Wei Gao   +8 more
doaj   +1 more source

Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non‐genetic Model to Study Hirschsprung Disease?

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
This study investigates the role of retinoic acid (RA) in intestinal development using the zebrafish. RA inhibition reduced enteric neurons and altered non‐neuronal cell populations. Compared to the ret mutant model, RA deficiency caused distinct shifts in epithelial, immune, and mesenchymal populations, highlighting RA's broader influence on ...
Naomi J. M. Kakiailatu, Wei Zhang, Laura E. Kuil, Eric Bindels, Joke T. M. Zink, Michael Vermeulen, Emma de Pater, Veerle Melotte, Maria M. Alves   +8 more
wiley   +1 more source

The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures

The International Journal of Developmental Biology, 2010
Two new components of the retinoic acid (RA) synthetic pathway, the cell surface receptor for retinol, Stra6, and the enzyme converting retinol into retinal, Rdh10, have recently been described. To understand how different tissues of the chick embryo generate different retinoid signatures, we describe the expression patterns of these two genes and ask ...
Susan, Reijntjes, Maija H, Zile, Malcolm, Maden   +2 more
openaire   +3 more sources

STRA6, a Cell-Surface Receptor for Retinol-Binding Protein: The Plot Thickens [PDF]

Cell Metabolism, 2007
How retinol (vitamin A) is taken up by cells has been an area of active research since the first report of a cell-surface receptor for retinol-binding protein (RBP) in the mid-1970s. Two recent reports, by Kawaguchi et al. (2007) and Pasutto et al. (2007), provide compelling data regarding the molecular identity and properties of a RBP receptor and ...
openaire   +2 more sources