Results 61 to 70 of about 600,912 (282)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Micro-scale full-field strain measurement on a stainless steel sample elasto-plastically tested [PDF]
, 2013 This study deals with the characterisation of the mechanical behaviour of an austenitic stainless steel at the micrometric scale in its elasto-plastic domain. For that, the full-field “grid method”, adapted to this scale, is implementeded.
MOULART, Raphaël, ROTINAT, René
core +3 more sources
Correlation between rearrangements and soft modes in polymer glasses during deformation and recovery
, 2015 We explore the link between soft vibrational modes and local relaxation events in polymer glasses during physical aging, active deformation at constant strain rate, and subsequent recovery.
Rottler, Joerg, Smessaert, Anton
core +1 more source
Mechanical noise dependent Aging and Shear Banding behavior of a mesoscopic model of amorphous plasticity [PDF]
, 2011 We discuss aging and localization in a simple "Eshelby" mesoscopic model of amorphous plasticity. Plastic deformation is assumed to occur through a series of local reorganizations.
Roux, Stéphane, Vandembroucq, Damien
core +5 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Flow transitions in two-dimensional foams
, 2006 For sufficiently slow rates of strain, flowing foam can exhibit inhomogeneous flows. The nature of these flows is an area of active study in both two-dimensional model foams and three dimensional foam. Recent work in three-dimensional foam has identified
C. Macosko +5 more
core +1 more source
Mathematical analysis of strain localization [PDF]
Revue Européenne de Génie Civil, 2007 ABSTRACT First it is shown by a simple one-dimensional example that stress-strain laws with softening cannot provide an objective description of response on the structural level. The phenomenon of discontinuous bifurcation from a uniform state is then analyzed in a general threedimensional setting.
openaire +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Polymer-like double necking deformation in an FeCoCrV medium entropy alloy
Materials Research LettersNecking in metallic materials is a crucial strain localization phenomenon traditionally regarded as the termination of uniform deformation and the sign of impending fracture.
Si Gao +8 more
doaj +1 more source
Parallel transport of local strains
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2018 Transporting deformations from a template to a different one is a typical task of the shape analysis.
F. Milicchio +5 more
openaire +3 more sources