Results 71 to 80 of about 600,912 (282)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Spin-Resolved Self-Doping Tunes the Intrinsic Half-Metallicity of AlN Nanoribbons

, 2013
We present a first-principles theoretical study of electric field-and strain-controlled intrinsic half-metallic properties of zigzagged aluminium nitride (AlN) nanoribbons.
Ganesh, P., Kent, Paul R. C., Lopez-Bezanilla, Alejandro, Sumpter, Bobby G.   +3 more
core   +1 more source

Local Strain Engineering in Atomically Thin MoS₂ [PDF]

Nano Letters, 2013
Tuning the electronic properties of a material by subjecting it to strain constitutes an important strategy to enhance the performance of semiconducting electronic devices. Using local strain, confinement potentials for excitons can be engineered, with exciting possibilities for trapping excitons for quantum optics and for efficient collection of solar
Andres CastellanosGomez, Rafael Roldán, Emmanuele Cappelluti, Michele Buscema, Francisco Guinea, Herre S J van der Zant, Gary A Steele   +6 more
openaire   +5 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of fibre orientation on the mechanical response of reinforced sand, detected with x-ray tomography [PDF]

E3S Web of Conferences
The mechanical behaviour of fibre-reinforced sands (FRS) has been thoroughly explored with a laboratory study, firstly investigating the influence of relevant parameters such as grading index, soil density, amount, diameter, and length of fibres then ...
Arciero Michela, Salvatore Erminio, Tengattini Alessandro, Modoni Giuseppe, Viggiani Gioacchino   +4 more
doaj   +1 more source

Morphologies of three-dimensional shear bands in granular media

, 2007
We present numerical results on spontaneous symmetry breaking strain localization in axisymmetric triaxial shear tests of granular materials. We simulated shear band formation using three-dimensional Distinct Element Method with spherical particles.
C. Lee, D. Daudon, D. E. Wolf, H. Sakaguchi, H. Tsunekawa, J. Desrues, J. Desrues, J. Kertész, J. Török, K. A. Alshibli, L. D. Landau, M. Oda, S. Fazekas, S. Fazekas, S. Luding, S. N. Batiste, T. Pöschel   +16 more
core   +1 more source

Rupture by damage accumulation in rocks [PDF]

, 2006
The deformation of rocks is associated with microcracks nucleation and propagation, i.e. damage. The accumulation of damage and its spatial localization lead to the creation of a macroscale discontinuity, so-called "fault" in geological terms, and to the
A Buchel, A Guarino, A Johansen, A Lin, AM Boullier, B Gutenberg, B Menendez, B Velde, C Marone, C Nicholson, C Scavia, CA Tang, CA Tang, CAJ Wibberley, CG Bufe, CG Sammis, CH Scholz, CH Scholz, D Amitrano, D Place, D Sornette, DA Lockner, DA Lockner, DA Lockner, David Amitrano, DE Moore, E Bouchaud, E Bouchaud, EM Schulson, F Kun, GCP King, H Nechad, HL Li, IG Main, J Biarez, J Kemeny, J Mori, J Rice, J Schmittbuhl, J Schmittbuhl, J Weiss, J Weiss, JC Jaeger, JVA Keller, JW Rudnicki, K Chen, K Mair, K Michibayashi, K Mogi, LS Costin, M Gerstenberger, P Cowie, P Grassberger, RL Kranz, RP Young, S Zapperi, S Zapperi, SC Jaume, SJD Cox, SR Brown, T Hirata, W Wang, YC Wang, Z Olami, Z Reches   +64 more
core   +4 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Surface flaws control strain localization in the deformation of Cu$\vert$Au nanolaminates

, 2019
We carried out matched experiments and molecular dynamics simulations of the compression of nanopillars prepared from Cu$\vert$Au nanolaminates with 25 nm layer thickness.
Gola, Adrien, Pastewka, Lars, Schwaiger, Ruth, Zhang, Guang-Ping   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source