Results 141 to 150 of about 1,042,917 (337)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Industrial production and temporary development after the Emilian Earthquake.

open access: yesItalian Journal of Planning Practice, 2014
The earthquake that on the 20th of May hit Emilia has not been one of the most disastrous in modern Italian history, but it has highlighted the problem of preservation of industrial activities during a reconstruction process.
Matteo Scamporrino
doaj  

From Master Plan to Vision Plan: The Changing Role of Plans and Plan making in City development (with reference to Mumbai) [PDF]

open access: yes
Master plans are the traditional instruments used by urban local governments in India as forward planning tools by anticipating urban development and making provisions for the same in terms of (a) the allocation of land for various uses, (b) the ...
Ramakrishna NALLATHIGA
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

The Role of Knowledge in the prevention of natural hazards and related risks.

open access: yesItalian Journal of Planning Practice, 2014
Human activities, especially over the last two centuries, have had a huge impact on the environment and the landscape. Mankind is able to control and induce landscape changes but is subject to natural processes and hazards due to severe and extreme ...
Enrico Miccadei, Tommaso Piacentini
doaj  

Further Education Funding Council : circular : 98/06 : strategic plans including financial forecasts : 1997-98 to 1999-2000 [PDF]

open access: yes, 1998
"Provides information derived from an analysis of strategic planning information provided to the Council by institutions in July 1997" -- front ...

core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

The Products of Research on Spatial Planning and Urban Development. An inquiry into the recent Italian planning literature.

open access: yesItalian Journal of Planning Practice, 2014
In Italy, recent University reforms, a research quality assessment exercise, and the selection of academics by means of innovative procedures are all accelerating the discussion on the specificity ofresearch on spatial planning and urban design.
Bruno Zanon
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy