Results 101 to 110 of about 178,636 (293)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

A Generalized Class of Estimators for Estimating Population Mean in the Presence of Non-Response

open access: yesJournal of Statistical Theory and Applications (JSTA), 2018
Koyuncu and Kadilar proposed an estimator based on single auxiliary variable with complete response in stratified random sampling. In this paper, we extended Koyuncu and Kadilar’s estimator to a more generalized class of estimators using two auxiliary ...
Iram Saleem   +2 more
doaj   +1 more source

WILCOXON ESTIMATOR BASED ON STRATIFIED RANDOM SAMPLE

open access: yesMemoirs of the Faculty of Science, Kyushu University. Series A, Mathematics, 1974
Let population with continuous and symmetric c.d.f. F(X-θ) be classified into preassigned number L of strata. Let Zi1, Zi2,...,Zini. be ni independent observations from the i-th stratum (i=1∼L).
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Improved Exponential Estimator in Stratified Random Sampling

open access: yes, 2009
In this article we have considered the problem of estimating the population mean. Y. in the stratified random sampling using the information of an auxiliary variable x which is correlated with y and suggested improved exponential ratio estimators in the ...
Kumar, Mukesh   +3 more
core  

Ratio Type Estimator of Ratio of Two Population Means in Stratified Random Sampling

open access: yes, 2012
A ratio estimator is proposed for the ratio of two population means using auxiliary information in stratified random sampling. Bias and mean squared error expressions are obtained under large sample approximation, and the proposed estimator is compared ...
Tailor, Rajesh   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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