Results 71 to 80 of about 397,778 (284)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Estimators In The Stratified Random Sampling [PDF]

, 2009
The Stratified Random Sampling is a well-known design in sampling theory. Especially, after the study of Kadilar and Cingi (2003), the adaptations of ratio estimators to the Stratified Random Sampling have increased seriously. In Chapter 6, the studies on the estimators in the Stratified Random Sampling are analyzed such as Shabbir and Gupta (2005 ...
Hulya Cingi, Cem Kadilar
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Types of sampling in research

Journal of the Practice of Cardiovascular Sciences, 2019
Sampling is one of the most important factors which determines the accuracy of a study. This article review the sampling techniques used in research including Probability sampling techniques, which include simple random sampling, systematic random ...
Pooja Bhardwaj
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

On Sampling Strategies for Neural Network-based Collaborative Filtering

, 2017
Recent advances in neural networks have inspired people to design hybrid recommendation algorithms that can incorporate both (1) user-item interaction information and (2) content information including image, audio, and text.
Bordes Antoine, Chen Tianqi, Chen Ting, Collobert Ronan, den Oord Aaron Van, Gopalan Prem K, Kingma Diederik, Krizhevsky Alex, Lin Xiao, Mikolov T, Reddi Sashank J, Rendle Steffen, Salakhutdinov Ruslan, Zhang Xiang, Zhao Peilin, Zheng Yin   +15 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dual Transformation of Auxiliary Variables by Using Outliers in Stratified Random Sampling

Mathematics
To estimate the finite population variance of the study variable, this paper proposes an improved class of efficient estimators using different transformations. When both the minimum and maximum values of the auxiliary variable are known and the ranks of
Mohammed Ahmed Alomair, Umer Daraz
doaj   +1 more source

Toward a principled sampling theory for quasi-orders

Frontiers in Psychology, 2016
Quasi-orders, that is, reflexive and transitive binary relations, have numerous applications. In educational theories, the dependencies of mastery among the problems of a test can be modeled by quasi-orders.
Ali Ünlü, Martin Schrepp
doaj   +1 more source

When outcome expectations become habitual: explaining vs. predicting new media technology use from a social cognitive perspective [PDF]

, 2007
This study examined the triadic relationship between expected outcomes, habit strength, and media technology use within the model of media attendance (Larose & Eastin, 2004).
Peters, Oscar
core   +1 more source