Results 71 to 80 of about 4,844,174 (339)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ground Strength Test Technique of Variable-Camber Wing Leading Edge

Biomimetics
Morphing wing technology is crucial for enhancing the flight performance of aircraft. To address the monitoring challenges of full-scale variable-camber leading edges under flight conditions, this study introduces a ground-based strength testing ...
Shanshan Li, Xianmin Chen, Zhigang Wang, Yuanbo Liang   +3 more
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Digital collaborative exploration and practice of ground vibration test for full-scale aircraft

Hangkong gongcheng jinzhan
The ground vibration test of full-scale aircraft has the characteristics of multiple coordination units, complex system, long implementation time and high risk.
BAI Chunyu, LIANG Sen, SONG Qiaozhi
doaj   +1 more source

A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach.

Age and Ageing, 2011
BACKGROUND the European Working Group on Sarcopenia in Older People has developed a clinical definition of sarcopenia based on low muscle mass and reduced muscle function (strength or performance). Grip strength is recommended as a good simple measure of
H. Roberts, H. Denison, H. Martin, H. Patel, H. Syddall, C. Cooper, A. Sayer   +6 more
semanticscholar   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

A review of experimental modal analysis methods and their applications in aerospace vehicles

Hangkong gongcheng jinzhan
Experimental modal analysis is a method of measuring the natural vibration characteristics of a structure through experiments. The analysis results are mainly used to modify the structural dynamic models and provide data support for structural dynamics ...
HUI Xinyu, LIU Fan, LI Xiaodong, SONG Qiaozhi   +3 more
doaj   +1 more source

Evaluation of ductile crack initiation limit using strain hardening exponent

Nihon Kikai Gakkai ronbunshu, 2016
Evaluation of ductile crack initiation limit without depending on materials was investigated. Ductile crack initiation behaviors were experimentally and analytically comprehended using Al alloy as non-ferrous metal in addition to two different steels. It
Takehisa YAMADA, Yoichi YAMASHITA, Sohei KANNA   +2 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source