Results 71 to 80 of about 682,980 (296)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evolution of microstructure and properties of Cu-4.5 wt.% Ag alloy prepared by vacuum horizontal continuous casting in solid solution and aging treatment

Materials Research Express, 2020
The vacuum horizontal continuous casting method was used for preparing Cu-4.5 wt.% Ag alloy rod containing few oxygen. The evolution of microstructure was observed by metallographic microscope (OM), scanning electron microscope (SEM) and transmission ...
Linsheng Tang, Weibin Xie, Xiangpeng Xiao, Huiming Chen, Hang Wang, Bin Yang   +5 more
doaj   +1 more source

Plastic collapse of pipe bends under combined internal pressure and in-plane bending [PDF]

, 2005
Plastic collapse of pipe bends with attached straight pipes under combined internal pressure and in-plane closing moment is investigated by elastic–plastic finite element analysis.
Li, H., Mackenzie, D., Robertson, A.C.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mechanical properties and strengthening mechanism of medium and high volume fraction SiCp/Al composites

Cailiao gongcheng
The medium and high volume fraction SiCp/Al composites were prepared by hot isostatic pressing powder metallurgy process with volume fractions of 35%, 45% and 55% using 2024 and 6061 aluminum alloys as the matrix, respectively. The effect of matrix alloy
CUI Yan, LIAO Jiajie, CAO Leigang, YANG Yue   +3 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Research progress in additive manufacturing of AlCoCrFeNi2.1 eutectic high-entropy alloys

Cailiao gongcheng
AlCoCrFeNi2.1 eutectic high-entropy alloy is characterized by a fine, homogeneous, and regular lamellar structure, as well as good organizational structure and mechanical properties with both strength and plasticity over a wide range of temperature (70 ...
QIU Hefang, YUAN Xiaojing, LUO Weipeng, ZHANG Ze, CHENG Chen, CUI Fanfan   +5 more
doaj   +1 more source

Synthesis, microstructure, and mechanical properties of in situ TiB2/Al-4.5Cu composites

Science and Engineering of Composite Materials, 2018
In situ TiB2/Al-4.5Cu composites with different TiB2 particle amounts were fabricated by the salt-metal reaction technique. The effects of in situ TiB2 on the microstructure and mechanical properties of Al-4.5Cu alloy were studied in this paper.
Li Hongying, Zhao Shouxin, Ou Yangxun, Lai Yongqiu   +3 more
doaj   +1 more source

Effect of different casting techniques on the microstructure and mechanical properties of AE44-2 magnesium alloy

Materials Research Express, 2020
AE44-2 magnesium (Mg) alloys were fabricated by gravity casting (GC), high pressure die casting (HPDC), and high vacuum assisted high pressure die casting (HVHPDC).
Taihe Le, Qi Wei, Jinhui Wang, Peipeng Jin, Mengru Chen, Jiaxuan Ma   +5 more
doaj   +1 more source

Experimental assessment and retrofit of full-scale models of existing RC frames [PDF]

, 2002
PSD tests on two full-scale models of existing non-seismic resisting RC frame structures are described. The testing program covered several aspects, namely assessment of seismic performance of existing frames without and with infill panels ...
Molina, J., Pinto, A. V., Varum, H.
core   +1 more source