Results 131 to 140 of about 2,464,725 (290)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Coronary artery calcium scoring in 2026: strengths, limitations, and optimized clinical use

Frontiers in Radiology
Coronary artery calcium (CAC) scoring on non-contrast ECG-gated CT remains a robust, reproducible marker of total coronary atherosclerotic burden with clear prognostic value and consistent risk reclassification beyond contemporary clinical calculators ...
Pierre Sabouret, Domenico Mario Giamundo, Julien Rosencher, Stefano Figliozzi, Stefano Figliozzi   +4 more
doaj   +1 more source

Adaptation and validation of a German version of the Strengths Use and Deficit Correction (SUDCO) questionnaire. [PDF]

PLoS One, 2021
Lorenz T, Heinitz K, Beer C, van Woerkom M.   +3 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Strength Use and Well-Being at Work among Teachers: The Mediating Role of Basic Need Satisfaction

Behavioral Sciences
Teachers’ well-being at work is an important indicator of their mental health. Strengths use has been identified as a significant predictor of enhanced well-being at work.
Cangpi Wei, Jiahe Su, Jingjing Zhao, Ke Ding, Feng Kong   +4 more
doaj   +1 more source

Healthcare technologies and professional vision [PDF]

, 2003
This paper presents some details from an observational evaluation of a computer assisted detection tool in mammography. The use of the tool, its strengths and weaknesses, are documented and its impact on reader's 'professional vision' (Goodwin 1994 ...
Hartswood, Mark, Procter, Rob, Rouncefield, Mark, Slack, Roger, Soutter, J., Voss, Alex   +5 more
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Strengths Perspective: How Social Work Students Use Mindfulness as a Self-Care Strategy

Social Sciences
(1) Background: As helping professionals, social workers are more susceptible to compassion fatigue, vicarious trauma, and burnout due to regular exposure to clients’ trauma, traumatic situations, and heavy caseloads.
Rosalind Evans, Alicia Hawley-Bernardez, Greg Gibbons   +2 more
doaj   +1 more source