Results 101 to 110 of about 236,402 (293)

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Production and purification of streptavidin with higher biotin-binding activity [PDF]

, 2015
The objective of this study was to develop practical, efficient method for production, purification and assay of  binding activity of streptavidin. Streptomyces avidinii was first propagated on agar plates, the bacterial cells on the agar were scrapped ...
Tarigan, Simson, ., Sumarningsih .
core   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Production and Bioseparation Applications of Polyhydroxyalkanoate Nano-Granules Functionalized with Streptavidin

Microorganisms
Rapidly growing industrial biotechnology and bio-manufacturing require simple and cost-effective bioseparation tools. A novel strategy of bioseparation based on the streptavidin-decorated polyhydroxyalkanoate (PHA) nano-granules was developed in this ...
Yuyan Zhang, Jiping Zhao, Hui Guo, Xiaoyun Lu, Dan Tan   +4 more
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Stable Single-Walled Carbon Nanotube−Streptavidin Complex for Biorecognition

, 2016
A novel method is described for preparing single walled carbon nanotube (SWNT)−streptavidin complexes via the biotin−streptavidin recognition. The complex shows stability in 18 days, strong biotin recognition capability, and excellent loading capacity ...
Kjeld G. H. Janssen (2159311), Jan Pieter Abrahams (1429531), Daniël C. de Geus (2311417), Heiko J. van der Linden (2159308), Linhua Jiang (2311432), Zunfeng Liu (2249602), Tjerk. H. Oosterkamp (2311423), Patrick Voskamp (2311429), Federica Galli (2311426), Thomas Hankemeier (135670), Maxim E. Kuil (2311420), René C. L. Olsthoorn (1967989)   +11 more
core   +1 more source

Stable Single-Walled Carbon Nanotube-Streptavidin Complex for Biorecognition [PDF]

, 2010
A novel method is described for preparing single walled carbon nanotube (SWNT)-streptavidin complexes via the biotin-streptavidin recognition. The complex shows stability in 18 days, strong biotin recognition capability, and excellent loading capacity ...
Abrahams, Jan Pieter, Abrahams, J.P., Jiang, L., Liu, Zunfeng, Voskamp, P., Linden, H.J. van der, van der Linden, Heiko J., Voskamp, Patrick, Kuil, M.E., Janssen, K.G.H., Janssen, Kjeld G. H., Liu, Z., Oosterkamp, Tjerk H., Hankemeier, Thomas, Jiang, Linhua, Kuil, Maxim E., Oosterkamp, T.H., Hankemeier, T., Olsthoorn, René C. L., Geus, D.C. de, Olsthoorn, R.R.C.L., de Geus, Daniël C., Galli, F., Galli, Federica   +23 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Biochemische Charakterisierung des zellulären Transportsystems C2IN-Streptavidin

, 2012
Das clostridiale C2-Toxin gehört zur Familie der binären ADP-ribosylierenden Toxine. Es besteht aus der Enzymkomponente C2I sowie der Translokationskomponente C2II.
Plunien, Rainer
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source