Results 51 to 60 of about 253,897 (321)

Global and local epidemiology of Group A Streptococcus indicates that naturally-acquired immunity is enduring and strain-specific [PDF]

arXiv, 2021
The bacterium Group A Streptococcus (Streptococcus pyogenes, GAS) is a human-specific pathogen and a major cause of global morbidity and mortality. Despite decades of research our knowledge of GAS infection and immunity is incomplete, hampering vaccine design and other efforts to reduce disease prevalence.
arxiv  

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-lactam antibiotics.

Clinical Infectious Diseases, 2019
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for ...
Kirsten Vannice, Jessica N. Ricaldi, S. Nanduri, F. Fang, J. Lynch, C. Bryson-Cahn, Theodore Wright, J. Duchin, M. Kay, S. Chochua, C. V. Van Beneden, B. Beall   +11 more
semanticscholar   +1 more source

Liver‐directed drugs for transthyretin‐mediated amyloidosis

Journal of the Peripheral Nervous System, Volume 27, Issue 4, Page 228-237, December 2022., 2022
Abstract Transthyretin‐mediated amyloidosis (ATTR) is a rare, under‐recognized, progressively debilitating, fatal disease caused by the aggregation and extracellular deposition of amyloid transthyretin (TTR) fibrils in multiple organs and tissues throughout the body.
Thomas H. Brannagan 3rd, John L. Berk, Julian D. Gillmore, Mathew S. Maurer, Márcia Waddington‐Cruz, Marianna Fontana, Ahmad Masri, Laura Obici, Michela Brambatti, Brenda F. Baker, Lisa A. Hannan, Gustavo Buchele, Nick J. Viney, Teresa Coelho, Jose Nativi‐Nicolau   +14 more
wiley   +1 more source

Trend of antibiotic susceptibility of Streptococcus pyogenes isolated from respiratory tract infections in tertiary care hospital in south Karnataka

Iranian Journal of Microbiology, 2019
Background and Objectives: Streptococcus pyogenes is recognized as an important pathogen of respiratory tract infections. The rapidly, emerging problem of antibiotic resistant Streptococcus pyogenes is a major issue nowadays.
Anupam Berwal, Kiran Chawla, Seema Shetty, Ashu Gupta   +3 more
doaj   +1 more source

Uji Aktivitas Anti bakteri Ekstrak Lidah Buaya (Aloe vera) terhadap Bakteri Pseudomonas aeruginosa dan Streptococcus pyogenes

Majalah Kedokteran Andalas, 2021
Lidah buaya merupakan family Liliaceae, yang diketahui sebagai tanaman alami untuk pengobatan serta mempunyai banyak manfaat, diantarannya anti inflamasi, anti bakteri, antikanker, antioksidan, antiulcer, antidiabetes. Tujuan: penelitian ini mencari tahu
dalila fakhira damanik, Monica -, Yuliani Mardiati Lubis, Meldawati -   +3 more
doaj   +1 more source

Review of Streptococcus pyogenes

, 2023
_Streptococcus pyogenes_, commonly known as group A _Streptococcus_ (GAS), is a bacterium that causes a wide range of clinical diseases. Its ability to cause superficial, invasive, and even life-threatening infections makes it an important pathogen that requires prompt diagnosis and treatment. It is a Gram-positive bacterium.
Thualfakar Hayder Hasan Abusaiba, Ali Abdul Hussein, Taghreed F. Almahbob   +2 more
openaire   +1 more source

Sepsis and survival in critically ill calves: Risk factors and antimicrobial use

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 374-389, January/February 2023., 2023
Abstract Background Sepsis is a life‐threatening disease for which critically important antimicrobials (CIA) frequently are used. Diagnostic and therapeutic guidelines for sepsis and critically ill calves are largely lacking. Objectives Identify factors associated with mortality in critically ill calves and describe bacteria obtained from blood ...
Mathilde L. Pas, Jade Bokma, Thomas Lowie, Filip Boyen, Bart Pardon   +4 more
wiley   +1 more source

The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system

Molecular Microbiology, Volume 118, Issue 6, Page 744-764, December 2022., 2022
Coxiella burnetii is an obligate intracellular bacterium and causative agent of Q fever. Here we report that the C. burnetii genome encodes 11 toxin–antitoxin systems, which is highly unusual for intracellular bacteria, and that one TA system is encoded on the large endogenous plasmid found in almost all C. burnetii isolates.
Shaun Wachter, Diane C. Cockrell, Heather E. Miller, Kimmo Virtaneva, Kishore Kanakabandi, Benjamin Darwitz, Robert A. Heinzen, Paul A. Beare   +7 more
wiley   +1 more source

Streptococcus salivarius 24SMBc Genome Analysis Reveals New Biosynthetic Gene Clusters Involved in Antimicrobial Effects on Streptococcus pneumoniae and Streptococcus pyogenes

Microorganisms, 2022
Streptococcus salivarius 24SMBc is an oral probiotic with antimicrobial activity against the otopathogens Streptococcus pyogenes and Streptococcus pneumoniae. Clinical studies have reinforced its role in reducing the recurrence of upper respiratory tract
Gaia Vertillo Aluisio, Ambra Spitale, Luca Bonifacio, Grete Francesca Privitera, Aldo Stivala, Stefania Stefani, Maria Santagati   +6 more
doaj   +1 more source