Results 71 to 80 of about 55,479 (273)

Utilizing network pharmacology and other tools to examine active components and mechanism of action of Magnolia officinalis rheum rhabarbarum decoction in treating Streptococcus pyogenes skin infections

Bioresources and Bioprocessing
Infections caused by Streptococcus pyogenes and the growing threat of antibiotic resistance pose significant global health challenges. This study investigates the antibacterial properties of Magnolia officinalis Rheum rhabarbarum Decoction against ...
Yuanhao Wang, Xinrui Wang, Xueying Zhang, Mengyi Pan, Mingyang Sun, Zhiguo chen, Yingli Song   +6 more
doaj   +1 more source

CRISPR-Cas in Streptococcus pyogenes [PDF]

RNA Biology, 2019
The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led to a revolution in genome editing and engineering technologies. Despite the fact that most applications emerged after the discovery of the type II-A CRISPR-Cas9 system of Streptococcus pyogenes, its biological importance in this organism has received little attention.
Anaïs Le Rhun, Andrés Escalera-Maurer, Majda Bratovič, Emmanuelle Charpentier   +3 more
openaire   +3 more sources

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection [PDF]

, 2015
The authors would like to thank the Horserace Betting Levy Board for funding the analysis of the eqbE mutant (ref: Vet/prj/758). The Horse Trust funded the collection of isolates from UK outbreaks of strangles (G1606).
Paillot, Romain, Waller, Andrew S, Steward, Karen F, Robinson, Carl, Holden, Matthew T G, Harris, Simon R, Parkhill, Julian, Webb, Katy S   +7 more
core   +1 more source

THE STREPTOCOCCUS PYOGENES IN GYNECOLOGICAL DISEASES. [PDF]

JAMA: The Journal of the American Medical Association, 1901
In 1899 I reported 7 cases 1 of pelvic inflammation operated on in the gynecological clinic of the Johns Hopkins Hospital, in which the streptococcus pyogenes was found to be the infecting agent. Since the publication of that article, and during my service in the hospital, 4 additional cases have been operated on in which this micro-organism was found ...
openaire   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Erythromycin-resistant Streptococcus pyogenes

Srpski arhiv za celokupno lekarstvo, 2004
Streptococcus pyogenes is the most prevalent cause of tonsillopharyngitis in children. The drug of choice for infections caused by this microorganism is penicillin. The problem of treating such infections arises when erythromycin-resistant strains occur.
Gordana, Lazarević, Suzana, Laban-Nestorović, Milica, Jovanović, Biljana, Potkonjak   +3 more
openaire   +2 more sources

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis [PDF]

, 2009
Background: Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in ...
Kehoe, M., Gottschalk, M, Mai, Nguyen Thi Hoang, Maskell, Duncan, Dowson, C G, Cherevach, I, Cambridge, Spratt, BG, Quail, M.A., Goodhead, Ian, Xu, J, Slater, J.D., Xu Jianguo, Maskell Duncan J., Nguyen, Tran Chinh, Inna Cherevach, Ian Goodhead, Sanders, M., Dowson, Christopher G., Whatmore Adrian M., Price, Claire, Price, C, Smith, Hilde E., Nicholas J Croucher, Dowson Christopher G., Schultz, C, Price Claire, Cherevach Inna, Newcastle, Neil Chanter, Mai, NT, Ward, P N, Rabbinowitsch Ester, Diep, To Song, Ngo, Thi Hoa, Goodhead, I., Holden, MT, Croucher, N., Thi Hoang Mai Nguyen, Claire Price, Iversen, P, Whatmore, A M, Jianguo, Xu, To, SD, Parkhill, Julian, Chanter, N, Croucher, NJ, Michael Kehoe, Chinh Nguyen Tran, Ye, Changyun, Tran Bich Chieu, Diep, T S, Holden, M T, Ngo Thi Hoa, Quail, MA, Nguyen, THM, Sanders Mandy, Iversen, P., Tran, BC, Sanders, M, Chinh, Nguyen Tran, Chieu, T B, Bentley, Stephen D., Mai, NTH, Nguyen, TC, Quail, M A, Changyun Ye, Ngo, T H, Holden, M.T.G., Croucher, N J, Whatmore, Adrian M., Hauser, H, Goodhead Ian, Leigh, J.A., Mungall, K, Holden, MTG, Cronin, Ann, Matthew T G Holden, Slater, Josh D., Maskell, Duncan J., Bentley, S., Sharp, S., Rabbinowitsch, E., Parkhill, J., Wageningen UR, The Netherlands, Sharp, S, Mungall, K., To Song Diep, Croucher Nicholas J., Hauser, Heidi, Xu, Jianguo, Iversen Pernille, Smith, H E, Universite de Montreal, Canada, Maskell, D.J., Michael A Quail, Stephen Bentley, Smith, HE, Croucher, Nicholas J., Nguyen Thi Hoang Mai, Karen Mungall, Barrell, B.G., Cronin Ann, Slater Josh D., Bentley, S, Smith, H.E., Schultsz, C, Nottingham, Parkhill Julian, Rabbinowitsch, Ester, Rabbinowitsch, E, Kehoe Michael, AHT, Copenhagen, Hoa Ngo, Thi, Marcelo Gottschalk, Ward, P.N., Leigh James A., Hauser, H., Schultsz, Constance, Hilde E Smith, Philip N Ward, Schultsz, C., Imperial College London, Gottschalk Marcelo, Chieu, Tran Bich, Chinh, NT, Adrian M Whatmore, Barrell, B G, Maskell, DJ, Barrell, Barclay G., Josh D Slater, Wellcome Trust, Slater, JD, To, Song Diep, Chieu Tran Bich, Changyun, Ye, Quail, Michael A., Thi Hoa Ngo, Sharp Sarah, Cherevach, I., Amsterdam, Spratt, B G, Gottschalk, Marcelo, Julian Parkhill, Spratt Brian G., Barrell, Bart G., Chanter, N., Mai, N T, Diep To Song, Schultsz Constance, Heidi Hauser, Maskell, D J, Ward Philip N., Dowson, CG, Slater, J D, Barrell Barclay G., Leigh, J A, Cherevach, Inna, Bentley, Stephen, Leigh, James A., Ngo, TH, Parkhill, J, Thi, HN, Constance Schultsz, Nguyen Tran Chinh, Holden, Matthew T. G., Iversen, Pernille, Barclay G Barrell, Chieu, TB, Whatmore, AM, Mungall Karen, Ward, Philip N., Cronin, A, Ester Rabbinowitsch, Barrell, BG, Quail Michael A., National Institute For Communicable Disease, Sanders, Mandy, Ye Changyun, Goodhead, I, Whatmore, A.M., Ye, C, Bentley Stephen, Brian G Spratt, Chanter Neil, Hauser Heidi, Warwick, Price, C., Cronin, A., Kehoe, M, Spratt, B.G., Holden Matthew T. G., Smith Hilde E., Duncan J Maskell, Chinh, N T, Sharp, Sarah, Chanter, Neil, Diep, TS, Hospital For Tropical Diseases, Vietnam, Pernille Iversen, Jianguo Xu, Leigh, JA, Nguyen, Thi Hoang Mai, Oxford, Gottschalk, M., Mandy Sanders, Spratt, Brian G., James A Leigh, Dowson, C.G., Ward, PN, Christopher G Dowson, Mungall, Karen, Ann Cronin, Kehoe, Michael, Sarah Sharp   +215 more
core   +1 more source

Salivaricin G32, a Homolog of the Prototype Streptococcus pyogenes Nisin-Like Lantibiotic SA-FF22, Produced by the Commensal Species Streptococcus salivarius

International Journal of Microbiology, 2012
Salivaricin G32, a 2667 Da novel member of the SA-FF22 cluster of lantibiotics, has been purified and characterized from Streptococcus salivarius strain G32.
Philip A. Wescombe, Kristin H. Dyet, Karen P. Dierksen, Daniel A. Power, Ralph W. Jack, Jeremy P. Burton, Megan A. Inglis, Anna L. Wescombe, John R. Tagg   +8 more
doaj   +1 more source