Results 81 to 90 of about 93,238 (289)

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

Streptococcus pyogenes and EBV coinfection in severe adult meningoencephalitis: a rare diagnosis in a diabetic patient

Frontiers in Cellular and Infection Microbiology
BackgroundIntracranial infection caused by Streptococcus pyogenes is extremely rare in adults. We report a case of Streptococcus pyogenes combined with Epstein-Barr virus (EBV) infection in cerebrospinal fluid (CSF), which was diagnosed by targeted next ...
Xiaoxia Yang, Zhenzhen Li, Xiaoqing Dai, Ting Chai, Shaojun Huang, Fen Hu   +5 more
doaj   +1 more source

Conserved and specific features of Streptococcus pyogenes and Streptococcus agalactiae transcriptional landscapes

BMC Genomics, 2019
Background The human pathogen Streptococcus pyogenes, or group A Streptococcus, is responsible for mild infections to life-threatening diseases. To facilitate the characterization of regulatory networks involved in the adaptation of this pathogen to its ...
Isabelle Rosinski-Chupin, Elisabeth Sauvage, Agnès Fouet, Claire Poyart, Philippe Glaser   +4 more
doaj   +1 more source

Streptococcus pyogenes Escapes from Autophagy [PDF]

Cell Host & Microbe, 2013
Autophagy is important for innate defense against intracellular bacteria, such as Group A Streptococcus (GAS). In this issue of Cell Host & Microbe, Barnett et al. (2013) demonstrate that the globally disseminated serotype M1T1 clone of GAS can evade autophagy via streptococcal cysteine protease SpeB-mediated degradation of ubiquitin-LC3 adaptor ...
openaire   +2 more sources

Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To answer the PICoS question ‘in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo‐periodontal lesions, traumatic occlusal forces, prosthesis‐ and tooth‐related factors ...
Inbar Eshkol‐Yogev, Nagore Ambrosio, Cheryl Somani, Elena Figuero, Lior Shapira, Janet Davies   +5 more
wiley   +1 more source

Carrying pharyngeal of Streptococcus pyogenes and sensitivity profiles in schoolchild from Cartagena

Duazary, 2015
To determine the frequency of carrying pharyngeal of Streptococcus pyogenes and their sensitivity profiles in schoolchildren from Cartagena. Analytical cross-sectional study, the sample was composed by 131 children. Strains of Streptococcus pyogenes were
Lucy Margarita Villafañe-Ferrer, Raimundo Castro-Orozco   +1 more
doaj  

Group a streptococcal serotypes isolated from healthy schoolchildren in iran [PDF]

, 2003
Serotypes of group A streptococci are still a major cause of pharyngitis and some post-infectious sequelae such as rheumatic fever. As part of the worldwide effort to clarify the epidemiological pattern of group A streptococci in different countries, the
Fazeli, M.R., Ghaemi, E., Johnson, D.R., Kaplan, E.L., Khodabakhshi, B., Tabarraei, A., Vakili, M.A.   +6 more
core  

Molecular Typing of Streptococcus pyogenes.

Nippon Saikingaku Zasshi, 1999
Streptococcus pyogenesは,ヒトに咽頭炎等の風邪様症状を起こすほか,皮膚化膿症,産辱熱,敗血症,さらには非化膿性の続発症としてリウマチ熱や急性糸球体腎炎など,さまざまな病態を引き起こすことが知られている。わが国では,小児の疾患として代表的な猩紅熱は1970年頃から減少し,これに代わるかのように1990年代初め頃より劇症型レンサ球菌感染症(TSLS)が出現するなど本菌感染症の病態が変化しているかにみえるが,いわゆる溶連菌感染症の患者数は減少していない。欧米においても,TSLSを含め侵襲性の重篤な症状を呈する本菌感染症が1980年半ば頃より増加し,分離菌株のサブタイピングがそれ以外の症状との比較のうえで行われている。本稿では,血清型の周期的な流行パターンや薬剤耐性の経年変化を含め,S.
T, Murase, R, Suzuki, S, Yamai
openaire   +3 more sources

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, EarlyView.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, EarlyView.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source