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A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan +6 more
wiley +1 more source

The Effect of Recombinant Tissue Plasminogen Activator (r-tPA) on Quantitation of Neutralising Anti-Streptokinase Antibodies

Iranian Journal of Allergy, Asthma and Immunology, 2004
The measurement of anti-streptokinase antibodies can distinguish the patients who may benefit from streptokinase and those who should be treated with some other thrombolytic regimen.
Afshin Afshari R. Elizbeth Holme
doaj

Fibrinogen‐binding M‐related proteins facilitate the recruitment of plasminogen by Streptococcus pyogenes

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Group A Streptococcus (GAS) M‐related proteins (Mrp) are dimeric α‐helical coiled‐coil cell‐wall‐attached proteins. During infection, Mrp recruit human fibrinogen (Fg) to the bacterial surface, enhancing phagocytosis resistance and promoting growth in human blood.
Emma‐Jayne Proctor +12 more
wiley +1 more source

Evaluation of In vivo Bioactivity of a Mutated Streptokinase

Novelty in Biomedicine, 2017
Background: Immunogenicity of Streptokinase, as a thrombolytic drug, has limited its clinical use. Elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of streptokinase is worthy. Recently, we
Marzieh Sameni +6 more
doaj

Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the READAPT Study

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable to large artery atherosclerosis (LAA) than other mechanisms. We investigated whether real‐world application may impact DAPT effectiveness and safety in the REAl‐life ...
Eleonora De Matteis +245 more
wiley +1 more source

Pretreatment Plasminogen Activator Inhibitor-1 (PAI-1) Level in the Failure of Streptokinase Therapy in Acute Myocardial Infaction

Journal of Research in Medical Sciences, 2004
Background: The risk for unsuccessful reperfusion after streptokinase therapy may be caused by the antifibrinolytic effect of platelet-derived type 1 plasminogen activator inhibitor (Pal-1) and antistreptokinase antibodies.
H Shemirani, M Tajmirriahi, A Rezaei, F Oreisi +3 more
doaj

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 15, Issue 3, March 2025.
Recombinant human prourokinase demonstrates comparable efficacy and safety outcomes to alteplase in acute ischemic stroke patients treated within 4.5 h. These findings support its potential as an alternative thrombolytic agent. ABSTRACT Background Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological ...
Muhammad Hassan Waseem +12 more
wiley +1 more source

Increasing recombinant protein production in E. coli via FACS‐based selection of N‐terminal coding DNA libraries

The FEBS Journal, Volume 292, Issue 5, Page 1070-1085, March 2025.
Here, we developed a previously undescribed method to increase recombinant protein production in E. coli by modifying DNA sequences coding for the N terminus of produced proteins. Using directed evolution and fluorescent activated cell sorting (FACS) with GFP tagging, we screened diverse N‐terminal sequences derived from DNA libraries.
Štěpán Herynek +6 more
wiley +1 more source

Side Effects of Intravenous Streptokinase in Different Age Groups Patients with Acute Myocardial Infarction

Armaghane Danesh Bimonthly Journal, 2014
Background & aim: Myocardial infarction is one of the most common cardiovascular diseases. Streptokinase is used in patients with myocardial infarction with ST-segment elevation.
M Behnam Moghadam +4 more
doaj

Stent Crumpling as a Complication of Percutaneous Coronary Intervention, a Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 2, February 2025.
The graphical description of stent crumpling and its management. ABSTRACT Stent crumpling is a rare but potentially life‐threatening complication of percutaneous coronary intervention (PCI). This report highlights a case of stent crumpling during a PCI procedure, its management, and the importance of advanced imaging techniques in diagnosing and ...
Maryam Mehrpooya +3 more
wiley +1 more source

myocardial infarction
medicine
internal medicine

humans
cardiology
chemistry

thrombolysis
fibrinolysis
surgery