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A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan +6 more
wiley +1 more source

Activity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes. [PDF]

PLoS ONE, 2017
Streptokinase is a virulence factor of streptococci and acts as a plasminogen activator to generate the serine protease plasmin which promotes bacterial metastasis.
Sian Huish, Craig Thelwell, Colin Longstaff +2 more
doaj +1 more source

Fibrinogen‐binding M‐related proteins facilitate the recruitment of plasminogen by Streptococcus pyogenes

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Group A Streptococcus (GAS) M‐related proteins (Mrp) are dimeric α‐helical coiled‐coil cell‐wall‐attached proteins. During infection, Mrp recruit human fibrinogen (Fg) to the bacterial surface, enhancing phagocytosis resistance and promoting growth in human blood.
Emma‐Jayne Proctor +12 more
wiley +1 more source

Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the READAPT Study

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable to large artery atherosclerosis (LAA) than other mechanisms. We investigated whether real‐world application may impact DAPT effectiveness and safety in the REAl‐life ...
Eleonora De Matteis +245 more
wiley +1 more source

Inactivation of the lysine binding sites of human plasminogen (hPg) reveals novel structural requirements for the tight hPg conformation, M-protein binding, and rapid activation

Frontiers in Molecular Biosciences, 2023
Accelerated activation of the human plasminogen zymogen (hPg) to two-chain active plasmin (hPm) is achieved following conformational changes induced by ligand-binding at the lysine-binding sites (LBSs) in four of the five hPg kringle domains.
Yetunde A. Ayinuola +2 more
doaj +1 more source

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 15, Issue 3, March 2025.
Recombinant human prourokinase demonstrates comparable efficacy and safety outcomes to alteplase in acute ischemic stroke patients treated within 4.5 h. These findings support its potential as an alternative thrombolytic agent. ABSTRACT Background Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological ...
Muhammad Hassan Waseem +12 more
wiley +1 more source

The Effect of Recombinant Tissue Plasminogen Activator (r-tPA) on Quantitation of Neutralising Anti-Streptokinase Antibodies

Iranian Journal of Allergy, Asthma and Immunology, 2004
The measurement of anti-streptokinase antibodies can distinguish the patients who may benefit from streptokinase and those who should be treated with some other thrombolytic regimen.
Afshin Afshari R. Elizbeth Holme
doaj

Increasing recombinant protein production in E. coli via FACS‐based selection of N‐terminal coding DNA libraries

The FEBS Journal, Volume 292, Issue 5, Page 1070-1085, March 2025.
Here, we developed a previously undescribed method to increase recombinant protein production in E. coli by modifying DNA sequences coding for the N terminus of produced proteins. Using directed evolution and fluorescent activated cell sorting (FACS) with GFP tagging, we screened diverse N‐terminal sequences derived from DNA libraries.
Štěpán Herynek +6 more
wiley +1 more source

Effect of Streptokinase on Hemostasis [PDF]

Blood, 1968
Abstract The effect of streptokinase on hemostasis was studied by direct observation of hemostatic plugs in the rabbit mesentery. Infusion of streptokinase did not produce dissolution of hemostatic plugs which were already formed. It did cause a delay in the formation of a platelet mass capable of arresting bleeding from injured vessels.
J F Mustard +5 more
openaire +3 more sources

Identification of potentially causative drugs associated with hypotension: A scoping review

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
Antihypertensives are just the tip of the iceberg of drugs that cause hypotension. This scoping review examines antihypertensive and nonantihypertensive drugs associated with hypotension, analysing 97 studies from 2013 to 2023. It examines the frequency of reporting and corresponding levels of evidence and evaluates the results taking into account ...
Nurunnisa Sari, Ulrich Jaehde, Anna Maria Wermund +2 more
wiley +1 more source

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