Results 211 to 220 of about 238,609 (328)

Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product

open access: yesProtein Science, Volume 35, Issue 3, March 2026.
Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo   +5 more
wiley   +1 more source

A Systematic Approach to Field Testing of Biological Products for Horticulture Is Required to Improve Food Security

open access: yesJournal of Sustainable Agriculture and Environment, Volume 5, Issue 1, March 2026.
ABSTRACT Food security challenges require immediate action to increase food production. Many biological products derived from plant, animal or microbial sources claim they sustainably increase yield, but there are concerns about biosecurity to be investigated before their introduction to the field.
Kay Howard, Kirsty L. Bayliss
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti   +5 more
wiley   +1 more source

Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus

open access: yesSmall Structures, Volume 7, Issue 3, March 2026.
This study reveals the cryo‐EM structure of the PsoA, a key hybrid PKS‐NRPS enzyme in fungal secondary metabolism. The findings uncover a dimeric architecture and the specific PsoA–PsoF interaction and identify a dynamic loop in the KS domain that acts as a checkpoint for polyketide chain length and methylation timing, providing fundamental molecular ...
Lei Sun   +5 more
wiley   +1 more source

Streptomyces amazonensis sp. nov. isolated from Madeira river sediments with genomic potential for secondary metabolite production. [PDF]

open access: yesBraz J Microbiol
de Neves KOG   +9 more
europepmc   +1 more source

Crystal structure of endo‐β‐N‐acetylglucosaminidase HSα

open access: yesActa Crystallographica Section F, Volume 82, Issue 3, Page 94-100, March 2026.
Structural analysis of the GH85 enzyme endo‐β‐N‐acetylglucosaminidase HSα reveals a novel domain that is potentially involved in complex N‐glycan recognition.The crystal structure of endo‐β‐N‐acetylglucosaminidase HSα (Endo HSα) was determined at 1.8 Å resolution, revealing that the enzyme is composed of five distinct domains.
Ikuya Kurauchi   +4 more
wiley   +1 more source

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