Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product
Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo +5 more
wiley +1 more source
High-quality genome sequence of five Antarctic actinomycetes: Micromonospora ureilytica DSM 120150, Nocardiopsis akebiae DSM 120151, Streptomyces fildesensis DSM 41987T, Streptomyces hypolithicus DSM 41950T and Streptomyces albidoflavus DSM 120149. [PDF]
Tarazona Janampa U +6 more
europepmc +1 more source
ABSTRACT Food security challenges require immediate action to increase food production. Many biological products derived from plant, animal or microbial sources claim they sustainably increase yield, but there are concerns about biosecurity to be investigated before their introduction to the field.
Kay Howard, Kirsty L. Bayliss
wiley +1 more source
An Eco-Friendly Synthesis and Characterization of Antibacterial, Antifungal, and Antioxidant Silver Nanoparticles From Bioactive Streptomyces sp. Strain WSN-2. [PDF]
Anjum MS +4 more
europepmc +1 more source
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Streptomyces spp. in Arid and Savannah Ecosystems: Effects on the Inhibition of Actinomycetoma Pathogens. [PDF]
Hamid ME +3 more
europepmc +1 more source
Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus
This study reveals the cryo‐EM structure of the PsoA, a key hybrid PKS‐NRPS enzyme in fungal secondary metabolism. The findings uncover a dimeric architecture and the specific PsoA–PsoF interaction and identify a dynamic loop in the KS domain that acts as a checkpoint for polyketide chain length and methylation timing, providing fundamental molecular ...
Lei Sun +5 more
wiley +1 more source
Streptomyces amazonensis sp. nov. isolated from Madeira river sediments with genomic potential for secondary metabolite production. [PDF]
de Neves KOG +9 more
europepmc +1 more source
Crystal structure of endo‐β‐N‐acetylglucosaminidase HSα
Structural analysis of the GH85 enzyme endo‐β‐N‐acetylglucosaminidase HSα reveals a novel domain that is potentially involved in complex N‐glycan recognition.The crystal structure of endo‐β‐N‐acetylglucosaminidase HSα (Endo HSα) was determined at 1.8 Å resolution, revealing that the enzyme is composed of five distinct domains.
Ikuya Kurauchi +4 more
wiley +1 more source

