Results 71 to 80 of about 988,438 (327)
Statewide survey for streptomycin-resistant fire blight in orchards [PDF]
, 2012 Streptomycin is the industry standard for managing fire blight on apples and pears. In 2002, streptomycin-resistance was confirmed in Wayne County and eradicated through prompt action.
Aldwinckle, Herb +3 more
core
BiologyPlant growth regulators (PGRs) are widely used to enhance table grape quality, yet cultivar-specific responses and microstructural outcomes remain insufficiently resolved.
Pengcheng Yang +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Antibacterial Effects of the Essential Oils of CommonlyConsumed Medicinal Herbs Using an In Vitro Model. [PDF]
, 2010 The chemical composition and antibacterial activity of essential oils from 10 commonly consumed herbs: Citrus aurantium, C. limon, Lavandula angustifolia, Matricaria chamomilla, Mentha piperita, M.
Brkic, D. +4 more
core +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Results of Treatment with Streptomycin Plus Pyrazinamide in Patients with Active Pulmonary Tuberculosis Despite Prolonged Treatment with Isoniazid Plus PAS [PDF]
, 1960 This report presents the findings during a year or more of observation of 20 South Indian patients who, after an initial course of isoniazid plus PAS, were treated with streptomycin plus pyrazinamide for active pulmonary tuberculosis.
Andrews, R H +3 more
core
Антибиотики и Химиотерапия, 2020 Addition of perfluorodecalin with gas-transporting function to the liquid medium during submerged cultivation of actinomycetes of the genus Streptomyces resulted in higher intensity and level of the biomass synthesis and increased production of ...
V. M. Bakulin +5 more
doaj
Selman Abraham Waksman — a Great Scientist and One of the Greatest Benefactors of Mankind
Aktualʹnaâ Infektologiâ, 2015 The article presents in chronological order the main aspects of the discovery of the first antituberculous drug — streptomycin and information about Nobel Prize winner in physiology and medicine of Ukrainian origin — Selman Abraham Waksman.
D.V. Rotar
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source