Results 71 to 80 of about 942,735 (331)
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
PdtaS Deficiency Affects Resistance of Mycobacteria to Ribosome Targeting Antibiotics
Frontiers in Microbiology, 2017 Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here,
Karolina Dadura +7 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2014 Background Buruli Ulcer (BU) is a tropical infectious skin disease that is currently treated with 8 weeks of intramuscular streptomycin and oral rifampicin. As prolonged streptomycin administration can cause both oto- and nephrotoxicity, we evaluated its
S. Klis +5 more
semanticscholar +1 more source
A Controlled Comparison of a Twice-Weekly and Three Once-Weekly Regimens in the Initial Treatment of Pulmonary Tuberculosis [PDF]
, 1970 value of a fully supervised twice-weekly regimen of high-dosage isoniazid plus streptomycin in the treatment of newly diagnosed tuberculous patients with drug-sensitive cultures.
Tuberculosis Chemotherapy Centre, Madras
core
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
Streptomycin potency is dependent on MscL channel expression
Nature Communications, 2014 The antibiotic streptomycin is widely used in the treatment of microbial infections. The primary mechanism of action is inhibition of translation by binding to the ribosome, but how it enters the bacterial cell is unclear.
I. Iscla +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Journal of Antimicrobial Chemotherapy, 2014 OBJECTIVES To evaluate gidB alterations for possible impact on the cumulative mechanism underlying the acquisition of high-level streptomycin resistance in Mycobacterium tuberculosis.
J. Verma +6 more
semanticscholar +1 more source
Nurses\u27 Alumnae Association Bulletin - Volume 3 Number 6 [PDF]
, 1945 My Thirty Months in a Jap Camp Alumnae Day Hi-Lights of the Alumnae Association Meetings New Linen System at Jefferson Welcome! Miss Jackson Condolences and Miscellaneous Items A Step Forward Bits of Chatter Concerning Jefferson Streptomycin Improvements
Jackson, Margaret M, Ullom, Madeline
core +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source