Results 171 to 180 of about 181,208 (343)

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Treatment Effects of Onion on Spermatogenesis in Streptozotocin-induced Diabetic Rat

Journal of Medicinal Plants, 2009
Background: Onion has significant blood sugar lowering action. Objective: Antioxidants have essential effect on spermatogenesis and sperm parameters. Streptozotocin can dioceses oxidative stress and changes in antioxidant capacity are considered to play ...
B Gholamhosini, A Khaki, HR Ahmadi-Ashtiani, Sh Rezazadeh, H Rastegar, F Fathiazad, M Ghanbari   +6 more
doaj  

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Urtica is a dioecious plant, which has been introduced in Iranian traditional medicine as anti-diabetes. Since, the metabolic disorder caused by diabetes causes secondary pathophysiologic changes in multiple organs of the body ...
T Rezaei Aref, B Minaii Zangii, M Latifpour   +2 more
doaj  

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin [PDF]

Eurasian Journal of Veterinary Sciences
Aim: Type 2 Diabetes Mellitus is a metabolic disorder characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or insufficiency.
Elif Gulbahce-Mutlu, Emine Arslan, Hilal Arikoglu   +2 more
doaj  

The Complex Relation of Branched‐Chain Amino Acids and Inflammation in the Obesity and Diabetes Context

Obesity Reviews, EarlyView.
ABSTRACT In a scenario with increasing cases of obesity and diabetes worldwide, branched‐chain amino acids (BCAA) metabolism has become an important factor in the understanding of these pathologies. More recently, its chronic high plasma levels have been postulated, alongside glucose, inflammatory factors, and other molecules, as an important ...
Bernardo Starling‐Soares, Monique Macedo Coelho, Bruna Guerra Campolina, Camila Kümmel Duarte, Tatiani Uceli Maioli   +4 more
wiley   +1 more source

Role of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on immediate implant placement in type 2 diabetic rats

Photochemistry and Photobiology, EarlyView.
This study evaluated the combined effects of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on bone repair around immediately placed implants in type 2 diabetic rats. Resveratrol improved glycemic control and body weight, while aPDT increased implant stability and bone mineralization.
Letícia Pitol‐Palin, Carolina Sayuri Wajima, Fábio Roberto de Souza Batista, Naara Gabriela Monteiro, Isadora Castaldi Sousa, Valdir Gouveia Garcia, Dóris Hissako Matsushita, Letícia Helena Theodoro, Roberta Okamoto   +8 more
wiley   +1 more source

Retraction of "Anti-diabetic Activity of Brucine in Streptozotocin-Induced Rats: <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Studies". [PDF]

ACS Omega
Khan NU, Qazi NG, Khan AU, Ali F, Hassan SSU, Bungau S.   +5 more
europepmc   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source