Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Study on the Dynamic Mechanical Response of Orthotropic Materials Under Biaxial Impact Loading. [PDF]
Pang S +8 more
europepmc +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Response of Plants to Touch Stress at Morphological, Physiological and Molecular Levels. [PDF]
Jędrzejuk A, Kuźma N.
europepmc +1 more source
Effect of deep margin elevation and cavity configuration on the mechanical behavior of endocrown restorations: a 3D finite element study. [PDF]
Mutlu ŞN, Sevgen D, Mohammadi R.
europepmc +1 more source
Research on the mechanical behavior of compression molding for simulated polymer-bonded explosives. [PDF]
Wu X, Tao J, Wang B, Ren H, Wang Y.
europepmc +1 more source
Stress Corrosion Cracking (SCC) Resistance of the AW-5083 Alloy with a Plasma Electrolytic Oxidation (PEO) Coating in the Presence of Chloride (Cl<sup>-</sup>). [PDF]
Hajdukiewicz G +3 more
europepmc +1 more source
Sintering and Processing-Dependent Mechanical Behavior of UHMWPE and Its Nanocomposites in the Presence of Microfine UHMWPE. [PDF]
Amada K +3 more
europepmc +1 more source
Rheological analysis in food processing: factors, applications, and future outlooks with machine learning integration. [PDF]
Chen Y +6 more
europepmc +1 more source

