Results 61 to 70 of about 569,363 (269)

Epigenetic mechanisms of stress and depression

Psychiatria Polska, 2019
Etiopatogeneza zaburzeń nastroju, nie jest w pełni poznana. Wśród możliwych przyczyn tych zaburzeń bierze się pod uwagę czynniki genetyczne. Dotychczas nie udało się zidentyfikować mutacji pojedynczego genu odpowiadającego za objawy kliniczne, dlatego w etiologii tych chorób sugeruje się udział mechanizmów epigenetycznych, które polegają na wywołaniu ...
Natalia, Chmielewska, Janusz, Szyndler, Piotr, Maciejak, Adam, Płaźnik   +3 more
openaire   +2 more sources

Stress vesicles link epidermal mechanotransduction to stem cell differentiation

Nature Communications
The skin exhibits extraordinary plasticity, enabling it to adapt to mechanical changes in the environment. While transient deformations are accommodated without lasting structural effects, sustained mechanical stress induces durable tissue changes.
Sixia Huang, Paola Kuri, Jonathan Zou, Adriana Blanco, Maxwell Marshall, Gabriella Rice, Stephen Prouty, Tzvete Dentchev, Miriam Doepner, Joel D. Boerckel, Brian C. Capell, Todd W. Ridky, Panteleimon Rompolas   +12 more
doaj   +1 more source

Effects of Psychological Stress on Spontaneous Itch and Mechanical Alloknesis of Atopic Dermatitis

Acta Dermato-Venereologica
Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as an intractable itch. Psychological stress has been suggested to play a role in the onset and worsening of AD symptoms.
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Tomohiro Tobita, Motoki Morita, Ying Zuo, Kotaro Honda, Yayoi Kamata, Kenji Takamori   +9 more
doaj   +1 more source

Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Inflammation and Regeneration, 2019
Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses.
Kentaro Maruyama, Eiji Nemoto, Satoru Yamada   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Plants Stress: Salt Stress and Mechanisms of Stress Tolerance

Current Agriculture Research Journal, 2023
A diverse combination of biotic and abiotic pressures makes up the environment that plants naturally inhabit. These pressures cause similarly complicated responses in plants. The purpose of the review is to critically evaluate the effects of various stress stimuli on higher plants with an emphasis on the typical and distinctive dose-dependent responses
openaire   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Periodic Mechanical Stress Stimulates GIT1-Dependent Mitogenic Signals in Rat Chondrocytes Through ERK1/2 Activity

Cellular Physiology and Biochemistry, 2018
Background/Aims: The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively, but the mechanisms whereby chondrocytes sense and respond to mechanical stimuli remain to be determined.
Kewei Ren, Jilei Tang, Xuefeng Jiang, Huiqing Sun, Luming Nong, Nan Shen, Yanqing Gu   +6 more
doaj   +1 more source

Effect of plasma sericin glutaraldehyde treatments on the low stress mechanical properties of micro denier polyester/cotton blended fabric. [PDF]

Sci Rep, 2022
Rajalakshmi M, Kubera Sampath Kumar S, Vasanth Kumar D, Siva Jagadish Kumar M, Prakash C.   +4 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source