Results 71 to 80 of about 569,363 (269)

Study on stress change law of coal body permeability improvement by mechanical reaming

Meikuang Anquan
Mechanical reaming, as a new type of coal seam pressure relief and permeability enhancement measure, can be widely applied to low permeability gas coal seams. In order to investigate the stress evolution law of mechanical reaming, the stress distribution
Haichun WANG, Dongji LEI, Zhenhua DAI, Jie QIN   +3 more
doaj   +1 more source

Effect of Lamination Angle and Thickness on Analysis of Composite Plate Under Thermo Mechanical Loading

Journal of Mechanical Engineering, 2017
Analytical formulation and solution of stress analysis of composite plate subjected to thermo mechanical loading for various ply orientation and thickness of lamina are studied.
Choudhury Arnab, Mondal Samar Chandra, Sarkar Susenjit   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

RAPID NONDESTRUCTIVE MECHANICAL STRESS CONTROL

Electrical engineering & Electromechanics, 2013
The paper considers problems of nondestructive mechanical stress control device design. An analytical expression for calculation of EMF induced in the measuring winding of a converter is obtained.
O.V. Nabokova, V.V. Kozlov, V.F. Bezotosniy   +2 more
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An experimental investigation on PZT behavior under mechanical and cycling loading

Journal of the Mechanical Behavior of Materials, 2013
The drive to produce electrical energy by directly compressing piezoceramic material using mechanical stress stands behind the present test series. To be able to correctly choose the right material, PZT disks manufactured by three different manufacturers
Abramovich Haim, Tsikchotsky Eugeny, Klein Gregory   +2 more
doaj   +1 more source

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source