Results 91 to 100 of about 7,660,214 (363)

Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Inflammation and Regeneration, 2019
Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses.
Kentaro Maruyama, Eiji Nemoto, Satoru Yamada   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Neural Mechanisms of Stress Resilience and Vulnerability [PDF]

Neuron, 2012
Exposure to stressful events can be differently perceived by individuals and can have persistent sequelae depending on the level of stress resilience or vulnerability of each person. The neural processes that underlie such clinically and socially important differences reside in the anatomical, functional, and molecular connectivity of the brain. Recent
Franklin Tamara B, Saab Bechara J, Mansuy Isabelle M   +2 more
openaire   +4 more sources

Mechanotransduction in fibroblasts [PDF]

, 2011
Response to mechanical stress is important for tissue homeostasis, tissue architecture and muscle regeneration. All cells of an organism are subject to at least one of three types of mechanical stress: compression, shear stress or tension.
Brosig, Michaela
core   +1 more source

Simulation Study on Local and Integral Mechanical Quantities at Single Trabecular Level as Candidates of Remodeling Stimuli

Journal of Biomechanical Science and Engineering, 2006
Mechanical quantities at the microstructural level play important roles as stimuli of trabecular bone remodeling by which cancellous bone maintains and adapts its trabecular structure to the mechanical environment.
Ken-ichi TSUBOTA, Taiji ADACHI
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mechanical stress facilitates calcium influx and growth of alveolar epithelial cells via activation of the BDKRB1/Ca2+/CaMKII/MEK1/ERK axis

Respiratory Research
Background Mechanical stress and calcium metabolism are associated with lung development and various pulmonary diseases. Our previous research demonstrated that BDKRB1/Ca2+ signal transduction may be involved in lung dysplasia resulting from scoliosis ...
Ying Zhang, Qing-dong Zhang, Quan Li, Zhi-yue Shi, Cheng Pan, Rong-shuang Yan, De-rui Fei, Shi-xin Xu, Yang Luo   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mechanical properties of mesoporous ceria nanoarchitectures [PDF]

, 2014
Architectural constructs are engineered to impart desirable mechanical properties facilitating bridges spanning a thousand meters and buildings nearly 1 km in height.
Sayle, T.X.T., Inkson, B.J., Sayle, D.C., Parker, Stephen C., Parker, S.C., Sayle, Thi X.T., Seal, Sudipta, Möbus, G., Inkson, Beverley J., Möbus, Günter, Seal, S.   +10 more
core   +1 more source

Stress vesicles link epidermal mechanotransduction to stem cell differentiation

Nature Communications
The skin exhibits extraordinary plasticity, enabling it to adapt to mechanical changes in the environment. While transient deformations are accommodated without lasting structural effects, sustained mechanical stress induces durable tissue changes.
Sixia Huang, Paola Kuri, Jonathan Zou, Adriana Blanco, Maxwell Marshall, Gabriella Rice, Stephen Prouty, Tzvete Dentchev, Miriam Doepner, Joel D. Boerckel, Brian C. Capell, Todd W. Ridky, Panteleimon Rompolas   +12 more
doaj   +1 more source