Results 101 to 110 of about 1,971,553 (284)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

EFFECT OF WORKPLACE STRESS ON JOB PERFORMANCE

Economic Review, 2015
The study examines the relationship between workplace stress and job performance. A survey method was employed to gather self-administered questionnaires from executive and non-executive employees of a leading private investment bank in Peninsular ...
Azman Ismail, Noorshafine Saudin, Yusof Ismail, Ainon Jauhariah Abu Samah, Norish Norsiah Aminudin   +4 more
doaj   +2 more sources

Music in the relief of stress and distress in cancer patients [PDF]

Revista Brasileira de Enfermagem
Objectives: to evaluate the effects of music on the physiological stress and distress of cancer patients being treated in a hospital. Methods: quasi-experimental study carried out with cancer patients hospitalized in the nursing wards of a public ...
Mariana Scheidegger dos Santos, Filipe de Moraes Thomaz, Rafael Tavares Jomar, Angela Maria Mendes Abreu, Gunnar Glauco De Cunto Carelli Taets   +4 more
doaj   +4 more sources

Physiological Studies of Heat Stress Acclimation During a Specific Exercise Regimen [PDF]

, 1982
Eleven subjects were used to determine if the exercise regimen of racquetball could be used as a heat stress acclimator. Core temperature, skin temperature, sweat production, and weight loss were recorded during a racquetball match.
Johnson, Alan M., Morgans, Leland F.
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions 2.0. [PDF]

Int J Mol Sci, 2023
Hasanuzzaman M, Fujita M.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamics in physiological acute stress response trajectories: uncovering latent variability

BMC Psychiatry
Background Acute stressors trigger an immediate physiological response, involving multiple intricating pathways. These adaptive physiological responses include, among other processes, an increase in heart rate (HR) and a decrease in heart rate ...
Shaked Rosenblum, Sharona L. Rab, Roee Admon   +2 more
doaj   +1 more source

Biophysical and biochemical constraints imposed by salt stress:Learning from halophyte

Frontiers in Plant Science, 2014
Soil salinization is one of the most important factors impacting plant productivity. About 3.6 billion of the world’s 5.2 billion ha of agricultural dryland have already suffered erosion, degradation and salinization.
Bernardo eDuarte, Noomene eSleimi, Isabel eCaçador   +2 more
doaj   +1 more source