Results 51 to 60 of about 246,608 (267)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Shock Wave Pressure Measurement and Calibration Method Based on Bar Pressure Sensor

Sensors
In order to correctly measure the shock wave pressure generated by a near-field explosion, and while considering the limitations of the measurement and calibration method of the current bar pressure sensor, an improved shock wave pressure measurement ...
Yong-Xiang Shi, Ying-Cheng Peng, Yuan-Ding Xing, Xue-Jie Jiao, Xiao-Fei Huang, Ze-Qun Ba   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stress-strain relationship of PDMS micropillar for force measurement application

EPJ Web of Conferences, 2017
There is an increasing interest to use polydimethylsiloxane (PDMS) based materials as bio-transducers for force measurements in the order of micro to nano Newton.
Johari Shazlina, Shyan L. Y.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

CSEE Journal of Power and Energy Systems
The spacer used in gas insulated switchgear (GIS) plays a vital role in its safe operation. The mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between them. During a
Chuang Wang, Kang Lei, Qing Sun, Hui Li, Jiawei Zhang, Lang Zhao, Zongren Peng   +6 more
doaj   +1 more source

Stress-Strain Measurement of Rubber with Optical Moiré Fringes

Journal of Physics: Conference Series, 2017
We use the moire fringes to measure true stress and true strain of a rubber specimen in tension, and analyze the stress-strain relationship. With the printed straight-line pattern on a specimen, the moire patterns appear when the specimen is stretched.
W. Sriklin, T. Sriwipat, P. Suwanna, S. Suwanna, E. Pongophas   +4 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Experimental study on electro-mechanical response characteristics of PZT5H piezoelectric ceramics under impact loading

Journal of Asian Ceramic Societies, 2021
Using Servo Testing Machine and Split Hopkinson Pressure Bar measurement device, an experimental study on the electro-mechanical characteristics of PZT5H piezoelectric ceramics under quasi-static and impact loading are carried out.
Zhengchun Xie, Xianyang Xu
doaj   +1 more source