Results 81 to 90 of about 1,454,667 (331)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

CSEE Journal of Power and Energy Systems
The spacer used in gas insulated switchgear (GIS) plays a vital role in its safe operation. The mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between them. During a
Chuang Wang, Kang Lei, Qing Sun, Hui Li, Jiawei Zhang, Lang Zhao, Zongren Peng   +6 more
doaj   +1 more source

Measurement of Flow-Rate, Liquid Level and Stress-Strains.

TEION KOGAKU (Journal of Cryogenics and Superconductivity Society of Japan), 1992
Control of cryogenic systems require flow-measurements and liquid level-measurements of cryogenic fluid. Further, stress-strain measurements are indispensable for mechanical strength testing of various materials of which cryogenic equipments compose. In this paper, measurement's principle and the way to use at low temperature are described in detail ...
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Propagation mechanism of non-uniform distribution of stress and strain in tension test [PDF]

, 2013
Elastic-plastic finite element analysis is carried out on tension test to check the uniformity of stress and strain that highly influences the result of numerical analysis in forming processes.
Akiyama, Masayoshi, Morimoto, Ryo
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Measuring nonlinear stresses generated by defects in 3D colloidal crystals

, 2016
The mechanical, structural and functional properties of crystals are determined by their defects and the distribution of stresses surrounding these defects has broad implications for the understanding of transport phenomena. When the defect density rises
Bierbaum, Matthew, Cohen, Itai, Lin, Neil Y. C., Schall, Peter, Sethna, James P.   +4 more
core   +1 more source

On-sample water content measurement for a complete local monitoring in triaxial testing of unsaturated soils [PDF]

, 2012
To provide a complete local monitoring of the state of an unsaturated soil sample during triaxial testing, a local water content measurement device was adapted to a triaxial device comprising the measurement of local displacements (Hall effect ...
Cui, Yu-Jun, Delage, Pierre, Munoz-Castelblanco, José, Pereira, Jean-Michel   +3 more
core   +6 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source