Results 101 to 110 of about 3,798,231 (274)
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Inertial Effects on the Stress Generation of Active Fluids [PDF]
arXiv, 2017 Suspensions of self-propelled bodies generate a unique mechanical stress owing to their motility that impacts their large-scale collective behavior. For microswimmers suspended in a fluid with negligible particle inertia, we have shown that the virial `swim stress' is a useful quantity to understand the rheology and nonequilibrium behaviors of active ...
arxiv
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
The Determination of Poisson's Ratio and of the Absolute Stress-variation of Refractive Index [PDF]
, 1921 F. Twyman, John Perry
openalex +1 more source
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Stress correlations in glasses [PDF]
arXiv, 2018 We rigorously establish that, in disordered three-dimensional (3D) isotropic solids, the stress autocorrelation function presents anisotropic terms that decay as $1/r^3$ at long-range, with $r$ the distance, as soon as either pressure or shear stress fluctuations are normal. By normal, we mean that the fluctuations of stress, as averaged over spherical
arxiv
On endothermic decompositions obstained by pressure; Part II, Transformations of energy by shearing stress [PDF]
, 1893 M. Carey Lea
openalex +1 more source
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source