Results 91 to 100 of about 6,289,847 (284)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study on Mechanical Response and Stress Environment Characteristics of Rock Mass with Through-Going Discontinuities

Applied Sciences
As large-scale continuous geological weak planes widely developed in deep mines, through-going discontinuities have a significant impact on the distribution of deep rock mass stress fields and the deformation and failure modes of surrounding rock and are
Hongwei Deng, Jingbo Xu, Jun Shen, Zeru Cui, Junren Deng   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Investigation of Stress Concentration Factors in Countersunk Holes of Biaxially Loaded Isotropic Plates

This study employs finite element analysis (FEA) and response surface methodology (RSM) to analyze the stress concentration factor (SCF) in a biaxially loaded isotropic plate with a central countersunk hole. A finite element model is built using ANSY and
Abdullah A. Jabri, Mohammad A. Gharaibeh
core   +1 more source

Geomechanics-based sweet spot prediction for ultra-deep clastic reservoirs in Kuqa depression of Tarim Basin

Frontiers in Earth Science
PetroChina Tarim Oilfield has established China’s largest ultra-deep hydrocarbon production base, with over 180 wells drilled to depths exceeding 6,000 m.
Yixiong Hu, Ke Xu, Ke Xu, Ke Xu, Ke Xu, Hui Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Penglin Zheng, Fang Yuan, Jianli Qiang, Mingjin Cai, Bingxu Yan, Wei Zhang, Chao Li, Shujun Lai, Yu Zhang, Qiuyu Chen   +18 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A study on finite element of pre damaged stress concentration factor for a composite laminate member with central circular.

, 2018
The study investigates the pre damaged stress concentration factor (SCF) for a composite laminate member (CLM) with central circular hole subjected to tensile loading.
Choudhry, Rizwan Saeed, Shah, Atta Ur Rehman, Saeed, Hasan Aftab, Ahmed, Tanveer   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Digital image correlation in the classroom: determining stress concentration factors with webcams

, 2012
In this study, we introduce graduate students to an experiment with digitalimage correlation (DIC). From an educational point of view, the aim is to get students familiar with basic aspects of stereovision and DIC, for example, speckle pattern, subset ...
Coppieters, Sam, Van Hecke, Renaat, Lava, Pascal, Debruyne, Dimitri, Van Houtte, Paul   +4 more
core   +1 more source

Stress concentration factors in uniplanar tubular KT-joints of jacket structures subjected to in-plane bending loads [PDF]

, 2016
In the present research, data extracted from the stress analysis of 46 finite element models, verified using test results obtained from an experimental investigation, were used to study the effect of geometrical parameters on the chord-side stress ...
Ahmadi, Hamid, Nejad, Ali Ziyaei
core   +1 more source