Results 101 to 110 of about 6,289,847 (284)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Analysis of stress concentration factor around the hole of syntactic foam tensile specimens
, 2016 Syntactic foam composed of fused borosilicate glass microballoons and vinyl ester resin matrix represents viability for using as lighter material in marine structure.
Islam, M. M. +2 more
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Analysis of Composite Material and Composite Joint [PDF]
فناوری در مهندسی هوافضا, 2018 A composite is commonly defined as a combination of two or more distinct materials, to create a new material with properties that cannot be achieved by any of the components acting alone. The growing use of composites for structural applications has made
sara keypour sangsari
doaj
Analysis of Stress Concentration in Functionally Graded Plates with Linearly Increasing Young's Modulus. [PDF]
Materials (Basel), 2023 Abdalla HMA, Casagrande D, De Bona F.
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Root Cause Assessment of Welded Satellite Gear Carrier Failure in a Bucket Wheel Excavator
Production Engineering ArchivesIn this study was investigated the fracture of the welded supporting structure of a satellite carrier of a bucket wheel excavator drive reducer. The research was aimed at identifying the root causes of the failure through an integrated failure analysis ...
Arsić Dušan +5 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Stress testing of real credit portfolios [PDF]
Stress testing has become a crucial point on the Basel II agenda, mainly as Pillar I estimates do not explicitly take portfolio concentration into account.
Mager, Ferdinand, Schmieder, Christian
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