Results 121 to 130 of about 11,866,665 (347)
Shiyou jixie, 2016 Radial constant temperature reactor usually has a double shell structure, and the inner shell is usually supported by stainless steel supporting ring.The safety and reliability of the inner support is very important for the safe operation of constant ...
Fu Wenjing, Liu Ming
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Applied SciencesAs large-scale continuous geological weak planes widely developed in deep mines, through-going discontinuities have a significant impact on the distribution of deep rock mass stress fields and the deformation and failure modes of surrounding rock and are
Hongwei Deng +4 more
doaj +1 more source
Assessment of residual stress using thermoelastic stress analysis
, 2011 The work described in this thesis considers the application of thermoelastic stress analysis (TSA) to theassessment of residual stresses in metallic materials. Residual stresses exist within almost all engineeringcomponents and structures.
Robinson, Andrew Ferrand
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Root Cause Assessment of Welded Satellite Gear Carrier Failure in a Bucket Wheel Excavator
Production Engineering ArchivesIn this study was investigated the fracture of the welded supporting structure of a satellite carrier of a bucket wheel excavator drive reducer. The research was aimed at identifying the root causes of the failure through an integrated failure analysis ...
Arsić Dušan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Analysis of Composite Material and Composite Joint [PDF]
فناوری در مهندسی هوافضا, 2018 A composite is commonly defined as a combination of two or more distinct materials, to create a new material with properties that cannot be achieved by any of the components acting alone. The growing use of composites for structural applications has made
sara keypour sangsari
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Numerical and experimental modelling of carrying elements of heavy metallurgical equipments [PDF]
Metalurgija, 2010 Carrying structures of heavy metallurgical equipments are during their operation often exposed to extreme loading. The short-term overloading of the structure results to high stresses in locations of their concentrations.
F. Trebuňa, F. Šimčák, A. Gmiterko
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