Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
On Shaft Fillet Stress Concentration [PDF]
, 2017 A shaft is typically loaded by three different load types; torsional, bending and normal load separately or more generally in combinations. In most cases the size of the shaft is controlled by the constraints on the maximum allowable deflection and ...
Pedersen, Niels Leergaard
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Effective Notch-Stress-Based Stress Concentration Factors of the Rib-Deck Weld in Orthotropic Steel Decks Considering the Effect of Asphalt Surfacing. [PDF]
Materials (Basel), 2023 Wang Q, Shi S, Yao Y, Wang Z, Fu Z.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Electric foot-shock stress drives TNF-alpha production in the liver of IL-6-deficient mice [PDF]
, 2004 Objectives: Accumulating evidence has shown that interleukin-6 (IL-6) has pleiotropic effects on a variety of biological functions, including its antiapoptotic potential during liver injury.
Chida, Y, Motomura, Y, Kubo, C, Sudo, N
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Experimental and Numerical Study on the Influence of Stress Concentration on the Flexural Stability of an Aluminium Hollow Tube. [PDF]
Materials (Basel), 2023 Radhakrishnan G +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Awareness of Stress Concentration Points for Prevention and Management of Periprosthetic Fractures Following Plate Installation Reinforcement: A Case Report. [PDF]
J Orthop Case Rep, 2023 Taniguchi H, Yoshimoto N, Okazaki K.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
A Bio-Inspired Bistable Piezoelectric Structure for Low-Frequency Energy Harvesting Applied to Reduce Stress Concentration. [PDF]
Micromachines (Basel), 2023 Wu N, Fu J, Xiong C.
europepmc +1 more source