Results 131 to 140 of about 11,866,665 (347)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Analysis of Stress Concentration in Functionally Graded Plates with Linearly Increasing Young's Modulus. [PDF]
Materials (Basel), 2023 Abdalla HMA, Casagrande D, De Bona F.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Failure Mechanisms of Basalt Fiber Concrete Under Splitting Tensile Tests and DEM Simulations
BuildingsTo address the cracking problem caused by the weak tensile performance of concrete, this study investigates the failure mechanisms of basalt fiber-reinforced concrete under different fiber contents, single-blend, and mixed-blend schemes through splitting
Linlin Jiang +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Stress testing credit risk: a survey of authorities' approaches [PDF]
This paper reviews the quantitative methods used at selected central banks to stress testing credit risk, focusing in particular on the methods used to link macroeconomic drivers of stress with bank specific measures of credit risk (macro stress test ...
Antonella Foglia
core
Although the investigation on the effect of loaded out-of-plane braces on the values of the stress concentration factor (SCF) in offshore tubular joints has been the objective of numerous research works, a number of quite important cases still exist that
Ahmadi, Hamid +1 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Functionally‐Graded Serrated Fangs Allow Spiders to Mechanically Cut Silk, Carbon and Kevlar Fibers
Advanced ScienceBefore humans and allegedly any animal group, spiders developed “functionally graded toothed blades” that cut one of the toughest biological materials: silk.
Gabriele Greco +4 more
doaj +1 more source
Applied SciencesUniaxial compression testing provides essential mechanical property characterization for intact rock specimens. The accuracy of specimen preparation critically affects compression test results through end-surface geometry deviations: parallelism ...
Fangcai Zhu +4 more
doaj +1 more source