Results 81 to 90 of about 6,289,847 (284)

Evaluation of residual stress relaxation and its effect on fatigue strength of AISI 316L stainless steel ground surfaces: Experimental and numerical approaches [PDF]

, 2013
This paper is aimed at evaluating the residual stress relaxation and its effect on the fatigue strength of AISI 316L steel ground surfaces in comparison to electro-polished surfaces.
SIDHOM, Habib, LAAMOURI, Adnen, BRAHAM, Chedly   +2 more
core   +1 more source

Experimental study on load transfer characteristics of fully bonded anchors in granite residual soil layer

Yantu gongcheng xuebao
There are abundant research results on the load transfer characteristics of the grout/ground interface of the ground anchors in the industry, but the problems in the cohesive soil layer are still confused such as interface bond stress concentration ...
FU Wenguang 1, 2, 3, QIANG Xiaojun 4, LANG Xiangwei 4, XIAO Liping 2, 3, 5
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Simulation on the Influence of Inclusion–Matrix Interaction on Crack Initiation and Growth in Hypo-Peritectic Steel

Metals
Hypo-peritectic steels are susceptible to interfacial cracking during thin-slab continuous casting, in which non-metallic inclusions play a critical role.
Yanan Zeng, Xiangkan Miao, Junguo Li, Yukang Yuan, Bingbing Ge, Yitong Wang, Yajun Wang   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dynamic Response and Fatigue Life Evaluation of Expansion Joint Anchorage Zones Made with Engineered Cementitious Composites Based on a Vehicle–Expansion Joint Coupled Model

Buildings
Expansion joint anchorage zones are prone to premature cracking and fatigue deterioration under repeated wheel impact and interfacial stress concentration.
Baixian Fu, Yao Ran, Qingtao Zhang, Yubing Liu, Kunmiao Xu, Yanhua Guan, Renjuan Sun, Yufei Wang, Zhenwang Fan   +8 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Three-Dimensional Numerical Simulation of Mechano-Electrochemical Coupling Behavior of Q420NS Steel with Different Corrosion Pit Morphologies Under Simulated South China Sea Environment

Journal of Marine Science and Engineering
The mechano-electrochemical coupling behavior of Q420NS steel containing pits in the South China Sea environment was investigated. A three-dimensional numerical model incorporating elastoplastic deformation and corrosion kinetics was developed using ...
Cheng Zeng, Zhilin Long
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Finite Element Analysis and Optimization of Internal Support Structure in Constant Temperature Reactor

Shiyou jixie, 2016
Radial constant temperature reactor usually has a double shell structure, and the inner shell is usually supported by stainless steel supporting ring.The safety and reliability of the inner support is very important for the safe operation of constant ...
Fu Wenjing, Liu Ming
doaj