Results 91 to 100 of about 373,674 (351)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

CONSTRUCTION OF DEFORMATION DIAGRAMS OF CONCRETE UNDER SHEAR BASED ON THE AUTHOR'S THEORY OF ANISOTROPIC MATERIALS POWER RESISTANCE TO COMPRESSION AND DEFORMATION THEORY OF PLASTICITY

International Journal for Computational Civil and Structural Engineering, 2019
The Aim of this work was the construction of a concrete deformation diagrams under shear on the basis of two approaches: the theory of anisotropic materials force resistance in compression and deformation theory of plasticity with the use of state ...
Boris Sokolov, Oleg Radaikin
doaj   +1 more source

Behaviour of traditional Portuguese timber roof structures [PDF]

, 2006
The aim of this paper is to present the results of a structural analysis of common trusses traditionally used in roof construction in Portugal. The study includes the results of a preliminary survey intending to assess the geometry, materials and on site
Branco, J., Cruz, P., Piazza, M., Varum, H.   +3 more
core   +1 more source

Internal Stress Diagrams of Sintering Stress versus Viscosity for Graded Multilayers

JSME International Journal Series A, 2003
The internal stress of graded powder compacts during sintering is analyzed by using plate theory with shrinkage and warpage taken into consideration. Diagrams giving the in-plane stress on the surface of the compacts, produced by mismatch and bending, are presented as a function of sintering stress and viscosity.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Phase Separation of Rigid-Rod Suspensions in Shear Flow

, 1999
We analyze the behavior of a suspension of rigid rod-like particles in shear flow using a modified version of the Doi model, and construct diagrams for phase coexistence under conditions of constant imposed stress and constant imposed strain rate, among ...
A.J. Liu, A.V. Bhave, A.W. El-Kareh, A.Y. Zubarev, C. Grand, C.R. Safinya, C.V. Chaubal, D. Bonn, D. Roux, D. Zwillinger, D.C. Roux, E. Cappelaere, F. Greco, G. Porte, G.H. Fredrickson, H. Rehage, H. See, J. D. Gunton, J. K. G. Dhont, J.F. Berret, J.F. Berret, J.F. Berret, J.F. Berret, J.R.A. Pearson, K.A. Koppi, K.I. Winey, L. D. Landau, L. Kramer, M. Doi, M. Doi, M. Goulian, M.E. Cates, M.E. Cates, M.E. Cates, M.M. Britton, N. Kuzuu, N.A. Spenley, N.A. Spenley, O. Diat, O. Diat, P. Boltenhagen, P. Boltenhagen, P. D. Olmsted, P. Español, P. G. de Gennes, P. G. Debenedetti, P. M. Chaikin, P. van der Schoot, P.A. Buinen, P.D. Olmsted, P.D. Olmsted, P.D. Olmsted, P.T. Callaghan, P.T. Mather, R. B. Israel, R.M. Kannan, R.W. Mair, R.W. Mair, S. Hess, S.L. Keller, T. Odijk, T.C. Lubensky, T.C.B. McLeish, V. Schmitt, V. Schmitt, Y. Pomeau, Y.T. Hu, Y.Y. Renardy   +67 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Elasticidade, plasticidade, histerese... e ondas

Revista Brasileira de Ensino de Física
Neste artigo é descrito um experimento que permite estudar as propriedades mecânicas de fios sob tração. O experimento requer um monocórdio, no qual o fio é esticado e tangido, um microcomputador com placa de som e um software para análise espectral do ...
Luiz André Mützenberg, Eliane Angela Veit, Fernando Lang da Silveira   +2 more
doaj  

Strain-induced energy band gap opening in two-dimensional bilayered silicon film

, 2015
This work presents a theoretical study of the structural and electronic properties of bilayered silicon films under in-plane biaxial strain/stress using density functional theory.
Ji, Zhonghang, Voon, Lok C. Lew Yan, Zhou, Ruiping, Zhuang, Yan   +3 more
core   +1 more source