Results 111 to 120 of about 371,044 (285)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Estimation of the current stress field and fault reactivation analysis in the Asmari reservoir, SW Iran

Petroleum Science, 2019
Knowing the current condition of the faults and fractures in a reservoir is crucial for production and injection activities. A good estimation of the fault reactivation potential in the current stress field is a useful tool for locating the appropriate ...
Majid Taghipour, Mohammad Ghafoori, Gholam Reza Lashkaripour, Nasser Hafezi Moghaddas, Abdullah Molaghab   +4 more
doaj   +1 more source

Analysis of equivalent substitution of rectangular stress block for nonlinear stress diagram

Mechanics
This article deals with the analysis of equivalency of the substitution of rectangular stress block for nonlinear stress diagram with descending branch for the calculation of flexural, eccentrically compressed and eccentrically tensioned reinforced concrete members of rectangular cross-section.
Dulinskas, Eugedijus-Juozas, Zabulionis, Darius   +1 more
openaire   +2 more sources

Density-operator evolution: Complete positivity and the Keldysh real-time expansion

, 2019
We study the reduced time-evolution of open quantum systems by combining quantum-information and statistical field theory. Inspired by prior work [EPL 102, 60001 (2013) and Phys. Rev. Lett.
Reimer, V., Wegewijs, M. R.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Specific Strength Under Combined Loading

Structural Mechanics of Engineering Constructions and Buildings
The work is devoted to the application of the concept of specific strength for the analysis of the degree of utilization of mechanical properties of beam material under combined loading.
Arslan K. Kurbanmagomedov, Evgeny M. Morozov   +1 more
doaj   +1 more source

A Linear Evolution for Non-Linear Dynamics and Correlations in Realistic Nuclei

, 2003
A new approach to high energy evolution based on a linear equation for QCD generating functional is developed. This approach opens a possibility for systematic study of correlations inside targets, and, in particular, inside realistic nuclei.
Adcox, Adcox, Adler, Adler, Adloff, Adloff, Ayala, Ayala, Ayala, Back, Back, Back, Back, Back, Balitsky, Balitsky, Balitsky, Bartels, Bartels, Bartels, Bartels, Bartels, Bazilevsky, Bearden, Bearden, Breitweg, Breitweg, Chekanov, Collins, Dunlop, E. Levin, Eskola, Ewerz, Golec-Biernat, Golec-Biernat, Golec-Biernat, Golec-Biernat, Gotsman, Gotsman, Gotsman, Gribov, Iancu, Jalilian-Marian, Jalilian-Marian, Jalilian-Marian, Jalilian-Marian, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kovner, Kowalski, Kuraev, Kwiecinski, Laenen, Levin, Levin, Levin, Lipatov, M. Lublinsky, McLerran, McLerran, McLerran, McLerran, McLerran, Milov, Mioduszewski, Mueller, Mueller, Mueller, Mueller, Mueller, Mueller, Munier, Munier, Sakaguci, Schwimmer, Stasto, Weigert, Xu   +84 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

渐开线少齿数齿轮齿形系数和应力修正系数的实验研究

Jixie chuandong, 2007
Experiment reseach about involute gear’s tooth form factor and stress correction factor by applying 30o tangent method is carried out. Tooth profile generating experiment to teeth number is carried out, measury tooth root chord at the critical section ...
孙伏, 张杰, 陈应舒
doaj