Results 51 to 60 of about 373,674 (351)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Sensitivity Analysis of Steel Box-Section Girders. [PDF]
, 2013 The paper deals with the load–carrying capacity stochastic variance based sensitivity analysis of thin–walled box–section girder subjected to pure bending. The lower– and uppe-r-bound load–capacity estimation is performed. The methodology is based on the
Kotełko, Maria, Lis, Paweł
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Combined load simulation vs component loads simulation in machine design: A case study [PDF]
FME Transactions, 2014 At a present level of technology, almost all machine parts are subjected to combined loads in real working condition. The aim of research described in this paper is to highlight the importance of combined load simulation for the calculation of machine ...
Momčilović Dejan B. +3 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Effect of Negative-Energy Shells on the Schwarzschild Black Hole [PDF]
, 2009 We construct Penrose diagrams for Schwarzschild spacetimes joined by massless shells of matter, in the process correcting minor flaws in the similar diagrams drawn by Dray and 't Hooft, and confirming their result that such shells generate a horizon ...
B. Carter +15 more
core +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Stress estimate in a multi-layer flexible pavement construction [PDF]
Строительство уникальных зданий и сооружений, 2015 The objective of the paper is providing experts with a procedure for stress estimate in a flexible pavement using tables, diagrams and nomograms. Müller nomograms ensure a reliable estimate of pavement stresses in a multi-layer flexible pavement ...
Mazic Branko, Mandic Aleksandra
doaj
Phase separation in a lattice model of a superconductor with pair hopping [PDF]
, 2012 We have studied the extended Hubbard model with pair hopping in the atomic limit for arbitrary electron density and chemical potential. The Hamiltonian considered consists of (i) the effective on-site interaction U and (ii) the intersite charge exchange ...
Bastide C +25 more
core +2 more sources
Network stress: A wiring diagram of whole stress genes
Horticulture ResearchAbstracts Stress sensitivity and tolerance are the consequences of coordinated regulation by multiple genes. Existing genetic tools can identify key genes that mediate metabolic and physiological processes sensing and perceiving stresses.
Yu Wang, Rongling Wu
openaire +1 more source