Results 61 to 70 of about 373,674 (351)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Determination of Limiting Deformations at Testing Cylindrical Samples for Tension

Проблеми трибології
This paper proposes a method for calculating limiting deformations under conditions of localized deformation during tensile testing. The method for calculating limiting deformations was used to construct plasticity diagrams under conditions of strain ...
I. Iu. Kyrytsya, O.V. Petrov, I.V. Vishtak, S.I. Sukhorukov   +3 more
doaj   +1 more source

Improvement of the mathematical model of the diagram of deformation of the compressed composite steel and concrete structures

MATEC Web of Conferences, 2017
The mathematical model of the stress-strain ratio of compressed concrete at elevated temperatures for composite structures described in Eurocode EN 1994-1-2:2005 Eurocode 4 divided in two stages: Stage 1 - represents the ascending branch and is defined ...
Fomin Stanislav, Izbash Yuriy, Plakhotnikova Iryna, Butenko Serhii, Shemet Ruslan   +4 more
doaj   +1 more source

(Non)-Renormalization of the Chiral Vortical Effect Coefficient [PDF]

, 2012
We show using diagramtic arguments that in some (but not all) cases, the temperature dependent part of the chiral vortical effect coefficient is independent of the coupling constant.
A Khare, Dam T. Son, DJ Gross, DT Son, E Witten, E Witten, J Erdmenger, J-H Gao, K Jensen, K Landsteiner, N Banerjee, N Banerjee, S Bhattacharyya, Siavash Golkar, SR Coleman, VP Nair, Y Neiman   +16 more
core   +2 more sources

Theoretical Forming Limit Diagram Based on Induced Stress in the Thickness Direction [PDF]

, 2023
Haibo Wang, Zipeng Wang
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Experimental methodology of study of damage initiation and development in textile composites in uniaxial tensile test [PDF]

, 2008
Damage in textile composites is closely connected with the internal micro- and meso-geometry of the reinforcement, and reveals features, which are not present in the damage processes in classical laminates. This paper proposes a test sequence intended to
Baudry, F., Ivanov, D, Lomov, S.V., Truong, T.C., Vanden Bosche, K., Verpoest, I., Xie, H   +6 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Interaction Diagrams of Short Rectangular RPC Columns Under Combined Axial Load Plus Uniaxial Bending

Journal of Engineering and Sustainable Development, 2014
Reactive Powder Concrete (RPC) represents one of the latest developments in concrete technology. The material and mechanical characteristics of RPC are significantly greater than the current ordinary concretes types classified as high-performance ...
Hisham Al-Hassani, Samer Hannawayya
doaj  

Two-loop MHV form factors from the periodic Wilson loop

Journal of High Energy Physics
We discuss how to compute maximal-helicity-violating (MHV) form factors for the chiral part of the stress-tensor supermultiplet from periodic light-like polygon Wilson loops in planar N $$ \mathcal{N} $$ = 4 super Yang-Mills theory beyond the one-loop ...
Zhenjie Li
doaj   +1 more source