Results 131 to 140 of about 70,206 (162)

Metabolites control stress granule disassembly

Nature Cell Biology, 2021
Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.
Christopher M. Jakobson, Daniel F. Jarosz   +1 more
openaire   +2 more sources

Stress granules plug holes

Science Signaling, 2023
Ruptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.
openaire   +2 more sources

Stress granules: regulators or by‐products?

The FEBS Journal, 2021
Cells have to deal with conditions that can cause damage to biomolecules and eventually cell death. To protect against these adverse conditions and promote recovery, cells undergo dramatic changes upon exposure to stress. This involves activation of signaling pathways, cell cycle arrest, translational reprogramming, and reorganization of the cytoplasm.
Daniel Mateju, Jeffrey A. Chao
openaire   +2 more sources

Yeast stress granules at a glance

Yeast, 2021
AbstractThe formation of stress granules (SGs), membrane‐less organelles that are composed of mainly messenger ribonucleoprotein assemblies, is the result of a conserved evolutionary strategy to cellular stress. During their formation, which is triggered by robust environmental stress, SGs sequester translationally inactive mRNA molecules, which are ...
Tomas Grousl, Jana Vojtova, Jiri Hasek, Tomas Vomastek   +3 more
openaire   +2 more sources

An Optimized Stress Granule Detection Method: Investigation of UBQLN2 Effect on Stress Granule Formation

2022
Stress granules (SGs) are cytosolic ribonucleoprotein granules that form via a liquid-liquid phase separation in response to environmental stresses such as heat, oxidative, and osmotic changes. Due to the condensation of low complexity, hydrophobic regions in core SG components in these highly dynamic granules, defects in SG maintenance and formation ...
Elizabeth J, Alexander, Jiou, Wang
openaire   +2 more sources

mRNPs: From informosomes to stress granules

Molecular Biology, 2010
Eucaryotic cytoplasmic mRNPs named when discovered "informosomes" are intensively investigated now as different mRNP granules. This review contains the data on structure and functioning of these mRNPs. The status of mRNA depends on spectrum of bound proteins and changes by signaling pathways.
A S, Voronina, E S, Pshennikova
openaire   +2 more sources

Mammalian Stress Granules and Processing Bodies

2007
The packaging of cytoplasmic mRNA into discrete RNA granules regulates gene expression by delaying the translation of specific transcripts. Specialized RNA granules found in germ cells direct the timing of maternal mRNA translation to promote germ cell development in the early embryo and establish the germ line for the next generation.
Nancy, Kedersha, Paul, Anderson
openaire   +2 more sources

FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins

Molecular and Cellular Biochemistry, 2018
Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules.
Kanako Ozeki, Mai Sugiyama, Khondker Ayesha Akter, Kimitoshi Nishiwaki, Eri Asano-Inami, Takeshi Senga   +5 more
openaire   +2 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly