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An Optimized Stress Granule Detection Method: Investigation of UBQLN2 Effect on Stress Granule Formation

2022
Stress granules (SGs) are cytosolic ribonucleoprotein granules that form via a liquid-liquid phase separation in response to environmental stresses such as heat, oxidative, and osmotic changes. Due to the condensation of low complexity, hydrophobic regions in core SG components in these highly dynamic granules, defects in SG maintenance and formation ...
Elizabeth J, Alexander, Jiou, Wang
openaire   +2 more sources

mRNPs: From informosomes to stress granules

Molecular Biology, 2010
Eucaryotic cytoplasmic mRNPs named when discovered "informosomes" are intensively investigated now as different mRNP granules. This review contains the data on structure and functioning of these mRNPs. The status of mRNA depends on spectrum of bound proteins and changes by signaling pathways.
A S, Voronina, E S, Pshennikova
openaire   +2 more sources

Mammalian Stress Granules and Processing Bodies

2007
The packaging of cytoplasmic mRNA into discrete RNA granules regulates gene expression by delaying the translation of specific transcripts. Specialized RNA granules found in germ cells direct the timing of maternal mRNA translation to promote germ cell development in the early embryo and establish the germ line for the next generation.
Nancy, Kedersha, Paul, Anderson
openaire   +2 more sources

FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins

Molecular and Cellular Biochemistry, 2018
Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules.
Kanako Ozeki   +5 more
openaire   +2 more sources

mRNA translation in stress granules is not uncommon

Nature Reviews Molecular Cell Biology, 2021
exaly  

Phase separation in stress resistance

Nature Reviews Molecular Cell Biology, 2022
exaly  

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

Cell, 2020
Jeffrey A Chao   +2 more
exaly  

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