Results 261 to 270 of about 77,443 (288)

Stress granules plug holes

Science Signaling, 2023
Ruptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.
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A Narrative Review on Stress Granules and Ultraviolet Stress Granules

Photobiomodulation, Photomedicine, and Laser Surgery
Background: Stress granules (SGs) are membraneless structures formed through liquid–liquid phase separation in response to cellular stress. These dynamic assemblies play a pivotal role in cellular adaptation and recovery from external stressors by modulating protein synthesis and preserving mRNA integrity ...
Yuru, Cheng, Shuzhen, Tan, Yi, Kong, Zhongrong, Liu   +3 more
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FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins

Molecular and Cellular Biochemistry, 2018
Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules.
Kanako Ozeki, Mai Sugiyama, Khondker Ayesha Akter, Kimitoshi Nishiwaki, Eri Asano-Inami, Takeshi Senga   +5 more
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An Optimized Stress Granule Detection Method: Investigation of UBQLN2 Effect on Stress Granule Formation

2022
Stress granules (SGs) are cytosolic ribonucleoprotein granules that form via a liquid-liquid phase separation in response to environmental stresses such as heat, oxidative, and osmotic changes. Due to the condensation of low complexity, hydrophobic regions in core SG components in these highly dynamic granules, defects in SG maintenance and formation ...
Elizabeth J, Alexander, Jiou, Wang
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Diversion of stress granules and P-bodies during viral infection

Virology, 2013
RNA granules are structures within cells that impart key regulatory measures on gene expression. Two general types of RNA granules are conserved from yeast to mammals: stress granules (SGs), which contain many translation initiation factors, and ...
Lucas C Reineke, Richard E Lloyd
exaly   +2 more sources

Stress granules and hormetic adaptation of cancer

Trends in Cancer, 2023
Cell stress is inherent to cancer and a key driver of tumorigenesis. Recent studies have proposed that cell stress promotes tumorigenesis through non-membranous organelles known as stress granules (SGs). While the biology of SGs is an emerging field, all studies to date point to the enhanced ability of cancer cells to form SGs compared with normal ...
Alexandra Redding, Elda Grabocka
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Metabolites control stress granule disassembly

Nature Cell Biology, 2021
Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.
Christopher M. Jakobson, Daniel F. Jarosz   +1 more
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Surviving Stress by Going to Stress Granules

Science's STKE, 2005
Cells and even entire animals exposed to nonlethal stress, such as exposure to high temperature, tolerate subsequent stresses that would be lethal to a cell or animal not thus preconditioned. One mechanism for this effect of heat-stress preconditioning is inhibition of the inflammatory pathway mediated by nuclear factor κB (NF-κB) and the ...
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Mammalian Stress Granules and Processing Bodies

2007
The packaging of cytoplasmic mRNA into discrete RNA granules regulates gene expression by delaying the translation of specific transcripts. Specialized RNA granules found in germ cells direct the timing of maternal mRNA translation to promote germ cell development in the early embryo and establish the germ line for the next generation.
Nancy, Kedersha, Paul, Anderson
openaire   +2 more sources

mRNA translation in stress granules is not uncommon

Nature Reviews Molecular Cell Biology, 2021
Kim Baumann, Baumann Kim
exaly