Results 91 to 100 of about 1,437,569 (357)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Threshold intensity factors as lower boundaries for crack propagation in ceramics

open access: yesBioMedical Engineering OnLine, 2004
Background Slow crack growth can be described in a v (crack velocity) versus KI (stress intensity factor) diagram. Slow crack growth in ceramics is attributed to corrosion assisted stress at the crack tip or at any pre-existing defect in the ceramic. The
Walter Per-Ole   +2 more
doaj   +1 more source

Shear-stress intensity factors for elastic sheets with cover plates [PDF]

open access: yes
Shear stress intensity factors are calculated for three problems concerning inextensible cover plates either bonded to or embedded in an elastic sheet which is under uniaxial tension.
Fichter, W. B.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Relation between intensity of singular stress at interface edge and stress intensity factor of small edge interface crack in butt joint

open access: yesNihon Kikai Gakkai ronbunshu, 2016
This paper deals with the effect of adhesion layer and material combination on the stress intensity factor for small edge interface crack in butt joint plate under uniaxial tension.
Kazuhiro ODA   +3 more
doaj   +1 more source

Stress intensity factors of interfacial cracks

open access: yesEngineering Fracture Mechanics, 1993
Abstract A comparison of mode I and II stress intensity factors at the interfacial crack tip arising from different applied loads and edge dislocation is made. Under the action of point load the stress intensity factor oscillates with the distance from the position of applied load to the crack tip, but there is no oscillation in the stress intensity ...
Zhang, Tongyi, Lee, Sanboh
openaire   +2 more sources

Application of fiber bridging models to fatigue crack growth in unidirectional titanium matrix composites [PDF]

open access: yes
Several fiber bridging models were reviewed and applied to study the matrix fatigue crack growth behavior in center notched (0)(sub 8) SCS-6/Ti-15-3 and (0)(sub 4) SCS-6/Ti-6Al-4V laminates.
Bakuckas, J. G., Jr., Johnson, W. S.
core   +1 more source

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