Results 51 to 60 of about 1,437,569 (357)

Measurement of the stress intensity factor and the effective stress intensity factor range of a mode I surface crack using the digital image correlation method

Nihon Kikai Gakkai ronbunshu, 2016
Crack opening displacement around a mode I surface crack tip was measured by digital image correlation method to determine the stress intensity factor and the effective stress intensity factor range.
Yuichi ONO, Satoshi SHIRAHASE, Keiji YAMAMOTO   +2 more
doaj   +1 more source

Criticality of porosity defects on the fatigue performance of wire + arc additive manufactured titanium alloy [PDF]

, 2019
This study was aimed at investigating the effect of internal porosity on the fatigue strength of wire + arc additive manufactured titanium alloy (WAAM Ti-6Al-4V).
Awd, Mustafa, Biswal, Romali, Ding, Jialuo, Syed, Abdul, Walther, Frank, Williams, Stewart, Zhang, Xiang   +6 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of stress intensity factor for small edge interface crack under thermal stress

Nihon Kikai Gakkai ronbunshu, 2015
This paper deals with the analysis of the thermal stress intensity factor for small edge interfacial crack between bonded dissimilar plates subjected to uniform change of temperature by using the crack tip stress method.
Kazuhiro ODA, Takayuki SHINMOTO, Nao-Aki NODA, Noriko TSUTSUMI   +3 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Study of the stress intensity factors in the bulk of the material with synchrotron diffraction [PDF]

, 2017
Artículo de Proceedings de Congreso Internacional Fatigue2017In this work we present the results of a hybrid experimental and analytical approach for estimating the stress intensity factor.
Buslaps, T, Lopez-Crespo, Pablo, Moreno-Morales, Maria Belen, Simpson, C, Vazquez-Peralta, J, Withers, P J   +5 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

STUDY ON STRESS INTENSITY FACTOR OF THREE DIMENSION MODEL OF TYPEⅠCRACK IN TYPICAL LUG JOINT

Jixie qiangdu, 2018
On the basis of two-dimension finite element analysis,the two-dimension stress intensity factor correction coefficients of typical lug joint were obtained; Three dimension elastic plastic contact finite element model of the typical lug joint was ...
WANG XinBo, WU LiMing, TAN ShengGang, ZHANG Sheng, WANG YaFan   +4 more
doaj  

Stress intensity factor in a tapered specimen [PDF]

The general problem of a tapered specimen containing an edge crack is formulated in terms of a system of singular integral equations. The equations are solved and the stress intensity factor is calculated for a compact and for a slender tapered specimen,
Erdogan, F., Xue-Hui, L.
core   +1 more source