A Physically Based Model Predicting the Degradation of Hydrogen on Crack Growth Critical Stress Intensity Factor of Metals [PDF]
, 2022 Yu‐Ting Huang +6 more
openalex +1 more source
Stress-intensity factor calculations using the boundary force method [PDF]
The Boundary Force Method (BFM) was formulated for the three fundamental problems of elasticity: the stress boundary value problem, the displacement boundary value problem, and the mixed boundary value problem.
Newman, J. C., Jr. +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strain intensity factor approach for predicting the strength of continuously reinforced metal matrix composites [PDF]
A method was previously developed to predict the fracture toughness (stress intensity factor at failure) of composites in terms of the elastic constants and the tensile failing strain of the fibers.
Poe, C. C., Jr.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Study of Effective Stress Intensity Factor through the CJP Model Using Full-Field Experimental Data. [PDF]
Materials (Basel), 2023 Camacho-Reyes A +3 more
europepmc +1 more source
Fatigue crack growth in unidirectional metal matrix composite [PDF]
The weight function method was used to determine the effective stress intensity factor and the crack opening profile for a fatigue tested composite which exhibited fiber bridging. The bridging mechanism was modeled using two approaches; the crack closure
Ghosn, Louis J. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Approximate determination of stress intensity factor for multiple surface cracks [PDF]
FME Transactions, 2018 In this paper a versatile and easy to use approximate procedure was used for the estimation of mode I stress intensity factors in case of multiple surface cracks in a three dimensional elastic body, subjected to remote uniaxial tensile loading.
Kastratović Gordana +3 more
doaj
Predicting Stress Intensity Factor for Aluminum 6062 T6 Material in L-Shaped Lower Control Arm (LCA) Design Using Extended Finite Element Analysis. [PDF]
Materials (Basel), 2023 El Fakkoussi S +5 more
europepmc +1 more source