Injustice perceptions about pain: parent–child discordance is associated with worse functional outcomes [PDF]
, 2018 Pain is experienced within and influenced by social environments. For children with chronic pain, the child–parent relationship and parental beliefs about pain are particularly important and may influence pain outcomes. Pain-related injustice perceptions
Hirsh, Adam T. +5 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Studying the Effect of Pulse Shape on Dynamic Stress Intensity Factor at the Finite Crack Tip using Displacement Fields [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2020 In analytical studies, step (Heaviside) function is used to simulate an impact load. However, in real behaviour of materials, loading and unloading take a short time.
Hossein Rahmani +1 more
doaj
Strain intensity factor approach for predicting the strength of continuously reinforced metal matrix composites [PDF]
A method was previously developed to predict the fracture toughness (stress intensity factor at failure) of composites in terms of the elastic constants and the tensile failing strain of the fibers.
Poe, C. C., Jr.
core +1 more source
A Continuum Theory of Crack Shielding in Ceramics [PDF]
, 1987 A phenomenological constitutive model is proposed which aims at describing the overall effect of microfracture in ceramics. Based on this model, the asymptotic stress, strain, and displacement fields at the tip of a stationary macroscopic crack are ...
Ortiz, M.
core
Crack path selection at the interface of wrought and wire+arc additive manufactured Ti–6Al–4V [PDF]
, 2016 Crack propagation deviation tendency in specimens containing an interface between wrought alloy substrate and Wire + Arc Additive Manufacture (WAAM) built Ti–6Al–4V is investigated from the viewpoints of microstructure, residual stress and bi-material ...
Addison +39 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The effect of broken stringers on the stress intensity factor for a uniformly stiffened sheet containing a crack [PDF]
A linear elastic stress analysis was made of a centrally cracked sheet stiffened by riveted, uniformly spaced and sized stringers. The stress intensity factor for the sheet and the load concentration factor for the most highly loaded stringer were ...
Poe, C. C., Jr.
core +1 more source
A Simplified Evaluation Method of the Stress Intensity Factor of a Circumferential Crack in a Cylinder Subjected to Axisymmetric Loads [PDF]
, 1997 A simplified method to approximately evaluate the stress intensity factor of an arbitrarily located circumferential crack in a cylinder subjected to axisymmetric loads was theoretically derived, based on the theory of cylindrical shell and compliance ...
飯井, 俊行, 渡邊, 勝彦
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source