Results 111 to 120 of about 2,487,134 (354)

The crack problem in bonded nonhomogeneous materials [PDF]

open access: yes
The plane elasticity problem for two bonded half planes containing a crack perpendicular to the interface was considered. The effect of very steep variations in the material properties near the diffusion plane on the singular behavior of the stresses and
Erdogan, Fazil   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Stress intensity factors of composite orthotropic plates containing periodic buffer strips [PDF]

open access: yes
The fracture problem of laminated plates which consist of bonded orthotropic layers is studied. The fields equations for an elastic orthotropic body are transformed to give the displacement and stress expressions for each layer or strip.
Delale, F., Erdogan, F.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Calculation and Analysis of Crack Stress Intensity Factor and J Integral of Helical Gear

open access: yesJixie chuandong, 2020
The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun   +2 more
doaj  

Stress-intensity factors for small surface and corner cracks in plates [PDF]

open access: yes
Three-dimensional finite-element and finite-alternating methods were used to obtain the stress-intensity factors for small surface and corner cracked plates subjected to remote tension and bending loads.
Atluri, S. N.   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Stress intensity factor in a tapered specimen [PDF]

open access: yes
The general problem of a tapered specimen containing an edge crack is formulated in terms of a system of singular integral equations. The equations are solved and the stress intensity factor is calculated for a compact and for a slender tapered specimen,
Erdogan, F., Xue-Hui, L.
core   +1 more source

A failsafe analysis using NASTRAN's piecewise linear analysis and a nine node linear crack element [PDF]

open access: yes, 1975
A two-dimensional crack element was implemented into NASTRAN as a user dummy element and used to study failsafe characteristics of the C5A fuselage. The element is formulated from Reitsner's functional requiring that it satisfy compatability with the ...
Kelley, J. W., Wilkinson, R. F.
core   +1 more source

Home - About - Disclaimer - Privacy