Results 81 to 90 of about 2,487,134 (354)

Numerical Estimation of Notch Stress Intensity Factors of Sharp V-Notches

open access: yesMATEC Web of Conferences, 2018
In the present work a simple and efficient least squares method is implemented for accurate estimation of notch stress intensity factors (NSIFs) of sharp V-notches.
Karim Hussain Mirzaul, Murthy K.S.R.K.
doaj   +1 more source

Stress analysis and stress intensity factors for finite geometry solids containing rectangular surface cracks [PDF]

open access: yes
The line method of analysis is applied to the Navier-Cauchy equations of elastic equilibrium to calculate the displacement field in a finite geometry bar containing a variable depth rectangular surface crack under extensionally applied uniform loading ...
Gyekenyesi, J. P., Mendelson, A.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Interlaminar crack growth in fiber reinforced composites during fatigue, part 3 [PDF]

open access: yes
Interlaminar crack growth behavior in fiber-reinforced composites subjected to fatigue loading was investigated experimentally and theoretically. In the experimental phase, inter-laminar crack propagation rates and mechanisms were determined for the ...
Wang, H. T., Wang, S. S.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The problem of internal and edge cracks in an orthotropic strip [PDF]

open access: yes
The plane elastostatic problem of internal and edge cracks in an infinite orthotropic strip is considered. The problems for the material types 1 and 2 are formulated in terms of singular integral equations.
Delale, F., Erdogan, F.
core   +4 more sources

Shot Peening Effect on Fatigue Crack Repaired Weldments

open access: yesAdvances in Materials Science and Engineering, 2017
Fracture mechanics calculations are required to validate the safety level defined in design codes to prevent a fatigue failure. The periodic inspection-assessment cycle can lead to the implementation of a fatigue crack repair by crack removal. To improve
J. Efrain Rodriguez-Sanchez   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy